Research Article

The Role of Microclot Formation in an Acute Subarachnoid Hemorrhage Model in the Rabbit

Figure 3

Evidence of microclot formation, neuronal apoptosis, and CPP depletion after experimental SAH. Quantification of TUNEL-positive cells and fibrinogen-positive stained microthrombi in cortex and hippocampus. (a) There were significant increases in the number of TUNEL-positive cells in both cerebral cortex and hippocampus as compared to controls ( and , resp., Student’s -test). (b) There was a nonstatistically significant trend towards an increase in fibrinogen-positive microvessels in the cerebral cortex ( ) and a statistically significant increase in fibrinogen-positive microvessels in the hippocampus ( ). No correlations of TUNEL-positivity with fibrinogen-positivity were observed in cortex ( ; (c)) or in hippocampus ( ; (d)). All data are expressed as mean ± SEM, in SAH group, and in control group. A value of 0.05 was considered statistically significant. (e) Time course of the CPP depletion after induction of SAH compared to control animals.
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