Derailed Intraneuronal Signalling Drives Pathogenesis in Sporadic and Familial Alzheimer’s Disease

Table 3

Binding partners of TAU (modified from [4, 192]).

Binding partner	Region of TAU involved	Function/identity of binding partner	References
-tubulin	Repeat domains	Cytoskeleton	[193]
F-actin		Cytoskeleton	[194]
ApoE3	Repeat domains	Lipid carrier	[195, 196]
Fgr	Proline-rich domain	Src kinase family	[89]
Fyn	Proline-rich domain	Src kinase family	[82, 89]
Lck	Proline-rich domain	Src kinase family	[82, 89]
cSrc	Proline-rich domain	Src kinase family	[82, 89]
Grb2	Proline-rich domain	Growth factor signalling	[89]
c-Abl		Src kinase family	[197]
p85	Proline-rich domain	Regulator PI3K, phospholipid signalling	[89]
PLCγ		Phospholipid signalling	[89, 198]
GSK3	N-terminal	Kinase	[199]
Calmodulin	Repeat domain	Ca^2+ signalling	[200, 201]
14-3-3	Proline-rich domain and repeat domain	Signalling scaffold	[202–204]
Annexin A2		Ca^2+ signalling, membrane trafficking	[205]
Pin1	Proline-rich domain	Peptidyl-prolyl cis/trans isomerase regulates phosphorylation of TAU	[206, 207]