Double-Bottom Chaotic Map Particle Swarm Optimization Based on Chi-Square Test to Determine Gene-Gene Interactions

Table 3

Estimation of the best protection model of gene-gene interaction on the occurrence of breast cancer as determined by PSO, CPSO, and DBMPSO.

	Combined; SNP	SNP; genotypes	Cases; number	Controls; number	𝜒^2 value	Odds; ratio	95% CI	𝑃 value
2-SNP
PSO	1,8	1-3	816	941	10.789	0.841	0.76–0.93	0.001
		Other	4184	4059
CPSO	1,8	1-3	816	941	10.789	0.841	0.76–0.93	0.001
		Other	4184	4059
DBMPSO	1,8	1-3	816	941	10.789	0.841	0.76–0.93	0.001
		Other	4184	4059
3-SNP
PSO	8,9,22	3-1-2	225	269	4.123	0.829	0.69–0.99	0.043
		Other	4775	4731
CPSO	3,8,9	1-3-1	319	371	4.209	0.850	0.73–0.99	0.040
		Other	4681	4629
DBMPSO	1,8,15	1-3-1	527	624	9.238	0.826	0.73–0.94	0.002
		Other	4473	4376
4-SNP
PSO	4,8,14,22	2-3-1-2	76	99	3.077	0.764	0.57–1.03	0.080
		Other	4924	4901
CPSO	10,17,21,23	2-1-1-1	223	268	4.337	0.824	0.69–0.99	0.038
		Other	4777	4732
DBMPSO	1,10,17,21	1-2-1-1	692	795	8.381	0.850	0.76–0.95	0.004
		Other	4308	4205
5-SNP
PSO	5,6,8,9,26	1-1-3-2-1	75	91	1.568	0.821	0.60–1.12	0.211
		Other	4925	4909
CPSO	2,4,8,11,18	1-2-3-1-2	32	44	1.909	0.726	0.46–1.15	0.169
		Other	4968	4956
DBMPSO	1,2,6,8,15	1-1-1-3-1	167	218	7.026	0.758	0.62–0.93	0.008
		Other	4833	4782
6-SNP
PSO	4,8,15,19,22,24	1-3-2-2-1-3	0	2	1.000	0.333	0.04–3.20	0.341
		Other	5000	4998
CPSO	3,4,12,16,20,24	1-1-1-2-2-3	21	28	1.005	0.749	0.43–1.32	0.318
		Other	4979	4972
DBMPSO	1,10,15,17,21,26	1-2-1-1-1-1	327	394	6.710	0.818	0.70–0.95	0.010
		Other	4673	4606
7-SNP
PSO	5,8,11,13,14,24,25	1-1-3-1-1-2-1	3	6	1.001	0.500	0.13–2.00	0.327
		Other	4997	4994
CPSO	10,12,16,17,19,22,26	2-2-2-1-2-2-1	20	27	1.047	0.740	0.41–1.32	0.308
		Other	4980	4973
DBMPSO	1,10,13,15,17,21,26	1-2-2-1-1-1-1	141	185	6.139	0.755	0.60–0.94	0.014
		Other	4859	4815