p53 Is a Key Regulator for Osthole-Triggered Cancer Pathogenesis
Figure 1
Osthole induces cell death in human colon cancer. Osthole-induced cell death of HCT116 and SW480 human colon cancer cells was shown. Cells were incubated with various concentrations of osthole (1, 3, or 10 μM) for 24 h, and the cell viability was examined by MTT (a) or SRB (b) assays. Results are expressed as the means ± S.E.M. from three independent experiments. , compared with the vehicle treatment group. (c) SW480 cells were incubated with osthole (10 μM) for indicated time periods, and the protein expressions of Bax, Bcl-2, procaspase-3, cleaved caspase-3, and PARP-1 were examined by western blot analysis. Results are the representative of three independent experiments.
