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BioMed Research International
Volume 2014, Article ID 175721, 8 pages
http://dx.doi.org/10.1155/2014/175721
Review Article

Regulation of p63 Protein Stability via Ubiquitin-Proteasome Pathway

Center of Growth, Metabolism and Aging, Key Laboratory of Biological Resources and Ecological Environment of Ministry of Education, College of Life Sciences, Sichuan University, Chengdu 610064, China

Received 25 December 2013; Revised 10 March 2014; Accepted 28 March 2014; Published 15 April 2014

Academic Editor: Xin-yuan Guan

Copyright © 2014 Chenghua Li and Zhi-Xiong Xiao. This is an open access article distributed under the Creative Commons Attribution License, which permits unrestricted use, distribution, and reproduction in any medium, provided the original work is properly cited.

Abstract

The p53-related p63 gene encodes multiple protein isoforms, which are involved in a variety of biological activities. p63 protein stability is mainly regulated by the ubiquitin-dependent proteasomal degradation pathway. Several ubiquitin E3 ligases have been identified and some protein kinases as well as other kinds of proteins are involved in regulation of p63 protein stability. These regulators are responsive to diverse extracellular signaling, resulting in changes of the p63 protein levels and impacting different biological processes.