Characterization of Imidazoline Receptors in Blood Vessels for the Development of Antihypertensive Agents

Figure 3

Effects of imidazoline receptor blockade on agmatine- or amiloride-induced vasodilatation. Effect of BU224 on concentration-dependent inhibition of agmatine- and amiloride- (10 μmol/L) induced relaxation in isolated aortic rings precontracted with 1 μmol/L phenylephrine ((a) and (b)) or 50 mmol/L KCl ((c) and (d)). All values are presented as mean ± SEM (𝑛=8). *𝑃<0.05 and **𝑃<0.01 as compared to agmatine-treated group.

(a)

(b)

(c)

(d)