Characterization of Imidazoline Receptors in Blood Vessels for the Development of Antihypertensive Agents

Figure 4

Effects of K_ATP blockade on agmatine- or amiloride-induced vasodilatation. Inhibitory effect of glibenclamide on the agmatine- or amiloride- (10 μmol/L) induced relaxation in isolated aortic rings precontracted with 1 μmol/L phenylephrine ((a) and (b)) or 50 mmol/L KCl (c and d). All values are presented as mean ± SEM (𝑛=8). *𝑃<0.05, **𝑃<0.01, and ***𝑃<0.001 as compared to the precontracted value.

(a)

(b)

(c)

(d)