Table of Contents Author Guidelines Submit a Manuscript
BioMed Research International
Volume 2014 (2014), Article ID 182862, 6 pages
http://dx.doi.org/10.1155/2014/182862
Research Article

Effect of Inflammatory Mediators on ATP Release of Human Urothelial RT4 Cells

Graduate School of Medicine, Illawarra Health and Medical Research Institute, University of Wollongong, Wollongong, NSW 2522, Australia

Received 28 February 2014; Accepted 2 April 2014; Published 15 April 2014

Academic Editor: Gilho Lee

Copyright © 2014 Kylie J. Mansfield and Jessica R. Hughes. This is an open access article distributed under the Creative Commons Attribution License, which permits unrestricted use, distribution, and reproduction in any medium, provided the original work is properly cited.

Linked References

  1. K. N. Moore, S. Murray, J. Malone-Lee, and A. Wagg, “Rapid urinalysis assays for the diagnosis of urinary tract infection,” British Journal of Nursing, vol. 10, no. 15, pp. 995–1001, 2001. View at Google Scholar · View at Scopus
  2. C. L. Lee, Y. H. Jiang, and H. C. Kuo, “Increased apoptosis and suburothelial inflammation in patients with ketamine-related cystitis: a comparison with non-ulcerative interstitial cystitis and controls,” BJU International, vol. 112, no. 8, pp. 1156–1162, 2013. View at Publisher · View at Google Scholar
  3. P. Aronsson, M. Johnsson, R. Vesela, M. Winder, and G. Tobin, “Adenosine receptor antagonism suppresses functional and histological inflammatory changes in the rat urinary bladder,” Autonomic Neuroscience: Basic and Clinical, vol. 171, no. 1, pp. 49–57, 2012. View at Publisher · View at Google Scholar
  4. F. Aldenborg, M. Fall, and L. Enerback, “Proliferation and transepithelial migration of mucosal mast cells in interstitial cystitis,” Immunology, vol. 58, no. 3, pp. 411–416, 1986. View at Google Scholar · View at Scopus
  5. P. M. Hanno, D. R. Staskin, and R. J. Krane, Interstitial Cystitis, Springer, New York, NY, USA, 1990.
  6. L. Enerback, M. Fall, and F. Aldenborg, “Histamine and mucosal mast cells in interstitial cystitis,” Agents and Actions, vol. 27, no. 1-2, pp. 113–116, 1989. View at Google Scholar · View at Scopus
  7. T. C. Theoharides, D. Kempuraj, and G. R. Sant, “Mast cell involvement in interstitial cystitis: a review of human and experimental evidence,” Urology, vol. 57, no. 6, supplement 1, pp. 47–55, 2001. View at Google Scholar · View at Scopus
  8. K. Moore, D. Richmond, and J. Sutherst, “Urinary acidity in relation to detrusor instability,” Neurourology and Urodynamics, vol. 9, pp. 331–332, 1990. View at Google Scholar
  9. K. Kjærgaard, M. A. Schembri, C. Ramos, S. Molin, and P. Klemm, “Antigen 43 facilitates formation of multispecies biofilms,” Environmental Microbiology, vol. 2, no. 6, pp. 695–702, 2000. View at Publisher · View at Google Scholar · View at Scopus
  10. Y. Cheng, N. J. C. King, and A. M. Kesson, “The role of tumor necrosis factor in modulating responses of murine embryo fibroblasts by flavivirus, West Nile,” Virology, vol. 329, no. 2, pp. 361–370, 2004. View at Publisher · View at Google Scholar · View at Scopus
  11. K. H. Moore, D. M. Hay, A. E. Imrie, A. Watson, and M. Goldstein, “Oxybutynin hydrochloride (3 mg) in the treatment of women with idiopathic detrusor instability,” British Journal of Urology, vol. 66, no. 5, pp. 479–485, 1990. View at Google Scholar · View at Scopus
  12. C. Walsh, A. Siddins, K. Parkin, C. Mukerjee, and K. H. Moore, “Prevalence of “low-count” bacteriuria in female urinary incontinence versus continent female controls: a cross-sectional study,” International Urogynecology Journal, vol. 22, no. 10, pp. 1267–1272, 2011. View at Publisher · View at Google Scholar · View at Scopus
  13. P. Abrams, L. Cardozo, M. Fall et al., “The standardisation of terminology of lower urinary tract function: report from the standardisation sub-committee of the International Continence Society,” Neurourology and Urodynamics, vol. 21, no. 2, pp. 167–178, 2002. View at Publisher · View at Google Scholar · View at Scopus
  14. D. A. Cockayne, S. G. Hamilton, Q.-M. Zhu et al., “Urinary bladder hyporeflexia and reduced pain-related behaviour in P2X3-deficient mice,” Nature, vol. 407, no. 6807, pp. 1011–1015, 2000. View at Publisher · View at Google Scholar · View at Scopus
  15. M. Vlaskovska, L. Kasakov, W. Rong et al., “P2X3 knock-out mice reveal a major sensory role for urothelially released ATP,” The Journal of Neuroscience, vol. 21, no. 15, pp. 5670–5677, 2001. View at Google Scholar · View at Scopus
  16. D. R. Ferguson, I. Kennedy, and T. J. Burton, “ATP is released from rabbit urinary bladder epithelial cells by hydrostatic pressure changes—a possible sensory mechanism?” The Journal of Physiology, vol. 505, part 2, pp. 503–511, 1997. View at Publisher · View at Google Scholar · View at Scopus
  17. V. Kumar, C. R. Chapple, A. M. Surprenant, and R. Chess-Williams, “Enhanced adenosine triphosphate release from the urothelium of patients with painful bladder syndrome: a possible pathophysiological explanation,” The Journal of Urology, vol. 178, no. 4, pp. 1533–1536, 2007. View at Publisher · View at Google Scholar · View at Scopus
  18. Y. Sun and T. C. Chai, “Augmented extracellular ATP signaling in bladder urothelial cells from patients with interstitial cystitis,” American Journal of Physiology: Cell Physiology, vol. 290, no. 1, pp. C27–C34, 2006. View at Publisher · View at Google Scholar · View at Scopus
  19. Y. A. N. Sun, S. Keay, P. G. de Deyne, and T. C. Chai, “Augmented stretch activated adenosine triphosphate release from bladder uroepithelial cells in patients with interstitial cystitis,” The Journal of Urology, vol. 166, no. 5, pp. 1951–1956, 2001. View at Google Scholar · View at Scopus
  20. V. Kumar, C. R. Chapple, D. Rosario, P. R. Tophill, and R. Chess-Williams, “In vitro release of adenosine triphosphate from the urothelium of human bladders with detrusor overactivity, both neurogenic and idiopathic,” European Urology, vol. 57, no. 6, pp. 1087–1092, 2010. View at Publisher · View at Google Scholar · View at Scopus
  21. Y. Cheng, K. J. Mansfield, W. Allen, C. A. Walsh, E. Burcher, and K. H. Moore, “Does adenosine triphosphate released into voided urodynamic fluid contribute to urgency signaling in women with bladder dysfunction?” The Journal of Urology, vol. 183, no. 3, pp. 1082–1086, 2010. View at Publisher · View at Google Scholar · View at Scopus
  22. Y. Cheng, K. J. Mansfield, W. Allen, R. J. Millard, E. Burcher, and K. H. Moore, “Correlation between cystometric volumes, ATP release, and pH in women with overactive bladder versus controls,” Neurourology and Urodynamics, vol. 32, no. 7, pp. 969–973, 2013. View at Publisher · View at Google Scholar
  23. C. A. Maggi, “Prostanoids as local modulators of reflex micturition,” Pharmacological Research, vol. 25, no. 1, pp. 13–20, 1992. View at Google Scholar · View at Scopus
  24. A. Ahluwalia, C. A. Maggi, P. Santicioli, A. Lecci, and S. Giuliani, “Characterization of the capsaicin-sensitive component of cyclophosphamide-induced inflammation in the rat urinary bladder,” British Journal of Pharmacology, vol. 111, no. 4, pp. 1017–1022, 1994. View at Google Scholar · View at Scopus
  25. A. Lecci, S. Giuliani, P. Santicioli, and C. A. Maggi, “Involvement of spinal tachykinin NK1 and NK2 receptors in detrusor hyperreflexia during chemical cystitis in anaesthetized rats,” European Journal of Pharmacology, vol. 259, no. 2, pp. 129–135, 1994. View at Publisher · View at Google Scholar · View at Scopus
  26. M. A. Vizzard, S. L. Erdman, and W. C. de Groat, “Increased expression of neuronal nitric oxide synthase in bladder afferent pathways following chronic bladder irritation,” The Journal of Comparative Neurology, vol. 370, no. 2, pp. 191–202, 1996. View at Google Scholar
  27. L. A. Birder, S. R. Barrick, J. R. Roppolo et al., “Feline interstitial cystitis results in mechanical hypersensitivity and altered ATP release from bladder urothelium,” American Journal of Physiology: Renal Physiology, vol. 285, no. 3, pp. F423–F429, 2003. View at Google Scholar · View at Scopus
  28. C. P. Smith, V. M. Vemulakonda, S. Kiss, T. B. Boone, and G. T. Somogyi, “Enhanced ATP release from rat bladder urothelium during chronic bladder inflammation: effect of botulinum toxin A,” Neurochemistry International, vol. 47, no. 4, pp. 291–297, 2005. View at Publisher · View at Google Scholar · View at Scopus
  29. Y. Cheng, K. J. Mansfiled, S. L. Sandow, P. Sadananda, E. Burcher, and K. H. Moore, “Porcine bladder urothelial, myofibroblast and detrusor muscle cells: characterisation and ATP release,” Frontiers in Pharmacology, vol. 2, article 27, 2011. View at Google Scholar
  30. A. Rosamilia, J. A. Clements, P. L. Dwyer, M. Kende, D. J. Campbell, and P. M. Hanno, “Activation of the kallikrein kinin system in interstitial cystitis,” The Journal of Urology, vol. 162, no. 1, pp. 129–134, 1999. View at Publisher · View at Google Scholar · View at Scopus
  31. K. Wirth, F. J. Hock, U. Albus et al., “Hoe 140 a new potent and long acting bradykinin-antagonist: in vivo studies,” British Journal of Pharmacology, vol. 102, no. 3, pp. 774–777, 1991. View at Google Scholar · View at Scopus
  32. M. Asano, N. Inamura, C. Hatori et al., “The identification of an orally active, nonpeptide bradykinin B2 receptor antagonist, FR173657,” British Journal of Pharmacology, vol. 120, no. 4, pp. 617–624, 1997. View at Publisher · View at Google Scholar · View at Scopus
  33. A. Ahluwalia and M. Perretti, “B1 receptors as a new inflammatory target. Could this B the 1?” Trends in Pharmacological Sciences, vol. 20, no. 3, pp. 100–104, 1999. View at Publisher · View at Google Scholar · View at Scopus
  34. F. Marceau, J. Barabe, S. St-Pierre, and D. Regoli, “Kinin receptors in experimental inflammation,” Canadian Journal of Physiology and Pharmacology, vol. 58, no. 5, pp. 536–542, 1980. View at Google Scholar · View at Scopus
  35. M. R. Ruggieri, J. Wang, and K. E. Whitmore, “Expression of bradykinin 1 receptor subtype in interstitial cystitis bladder biopsies,” The Journal of Urology, vol. 157, pp. 131–136, 1997. View at Google Scholar
  36. S. Meini, A. Lecci, P. Cucchi, R.-M. Catalioto, M. Criscuoli, and C. A. Maggi, “Inflammation modifies the role of cyclooxygenases in the contractile responses of the rat detrusor smooth muscle to kinin agonists,” The Journal of Pharmacology and Experimental Therapeutics, vol. 287, no. 1, pp. 137–143, 1998. View at Google Scholar · View at Scopus
  37. A. Lecci, S. Meini, M. Tramontana, S. Giuliani, M. Criscuoli, and C. A. Maggi, “Kinin B1 receptor-mediated motor responses in normal or inflamed rat urinary bladder in vivo,” Regulatory Peptides, vol. 80, no. 1-2, pp. 41–47, 1999. View at Publisher · View at Google Scholar · View at Scopus
  38. B. Chopra, S. R. Barrick, S. Meyers et al., “Expression and function of bradykinin B1 and B2 receptors in normal and inflamed rat urinary bladder urothelium,” The Journal of Physiology, vol. 562, no. 3, pp. 859–871, 2005. View at Publisher · View at Google Scholar · View at Scopus
  39. P. Ochodnický, M. B. Michel, J. J. Butter, J. N. Panicker, and M. C. Michel, “Bradykinin modulates spontaneous nerve growth factor production and stretch-induced ATP release in human urothelium,” Pharmacological Research, vol. 70, no. 1, pp. 147–154, 2013. View at Publisher · View at Google Scholar
  40. A. L. S. John and S. N. Abraham, “Innate immunity and its regulation by mast cells,” The Journal of Immunology, vol. 190, no. 9, pp. 4458–4463, 2013. View at Publisher · View at Google Scholar
  41. G. R. Sant, D. Kempuraj, J. E. Marchand, and T. C. Theoharides, “The mast cell in interstitial cystitis: role in pathophysiology and pathogenesis,” Urology, vol. 69, no. 4, supplement, pp. S34–S40, 2007. View at Publisher · View at Google Scholar · View at Scopus
  42. T. Sakai, K.-I. Kasahara, K.-I. Tomita, I. Ikegaki, and H. Kuriyama, “5-Hydroxytryptamine-induced bladder hyperactivity via the 5-HT2A receptor in partial bladder outlet obstruction in rats,” American Journal of Physiology: Renal Physiology, vol. 304, no. 7, pp. F1020–F1027, 2013. View at Publisher · View at Google Scholar
  43. T. Lundeberg, H. Liedberg, L. Nordling, E. Theodorsson, A. Owzarski, and P. Ekman, “Interstitial cystitis: correlation with nerve fibres, mast cells and histamine,” British Journal of Urology, vol. 71, no. 4, pp. 427–429, 1993. View at Google Scholar · View at Scopus
  44. M. Andersson, P. Aronsson, D. Giglio, A. Wilhelmson, P. Jeřábek, and G. Tobin, “Pharmacological modulation of the micturition pattern in normal and cyclophosphamide pre-treated conscious rats,” Autonomic Neuroscience: Basic and Clinical, vol. 159, no. 1-2, pp. 77–83, 2011. View at Publisher · View at Google Scholar · View at Scopus
  45. Z.-Y. Wang, P. Wang, and D. E. Bjorling, “Role of mast cells and protease-activated receptor-2 in cyclooxygenase-2 expression in urothelial cells,” American Journal of Physiology: Regulatory Integrative and Comparative Physiology, vol. 297, no. 4, pp. R1127–R1135, 2009. View at Publisher · View at Google Scholar · View at Scopus
  46. V. Y. Hu, S. Malley, A. Dattilio, J. B. Folsom, P. Zvara, and M. A. Vizzard, “COX-2 and prostanoid expression in micturition pathways after cyclophosphamide-induced cystitis in the rat,” American Journal of Physiology: Regulatory Integrative and Comparative Physiology, vol. 284, no. 2, pp. R574–R585, 2003. View at Google Scholar · View at Scopus
  47. K. Matsumoto-Miyai, A. Kagase, Y. Murakawa, Y. Momota, and M. Kawatani, “Extracellular Ca2+ regulates the stimulus-elicited ATP release from urothelium,” Autonomic Neuroscience: Basic and Clinical, vol. 150, no. 1-2, pp. 94–99, 2009. View at Publisher · View at Google Scholar · View at Scopus
  48. C. L. Parsons, “The therapeutic role of sulfated polysaccharides in the urinary bladder,” Urologic Clinics of North America, vol. 21, no. 1, pp. 93–100, 1994. View at Google Scholar · View at Scopus
  49. J. P. Lavelle, S. A. Meyers, W. G. Ruiz, C. A. T. Buffington, M. L. Zeidel, and G. Apodaca, “Urothelial pathophysiological changes in feline interstitial cystitis: a human model,” American Journal of Physiology: Renal Physiology, vol. 278, no. 4, pp. F540–F553, 2000. View at Google Scholar · View at Scopus
  50. G. Apodaca, S. Kiss, W. Ruiz, S. Meyers, M. Zeidel, and L. Birder, “Disruption of bladder epithelium barrier function after spinal cord injury,” American Journal of Physiology: Renal Physiology, vol. 284, no. 5, pp. F966–F976, 2003. View at Google Scholar · View at Scopus
  51. J. R. Hand, “Interstitial cystitis: report of 223 cases (204 women and 19 men),” The Journal of Urology, vol. 61, no. 2, pp. 291–310, 1994. View at Google Scholar
  52. T. J. Christmas, J. Rode, C. R. Chapple, E. J. G. Milroy, and R. T. Turner-Warwick, “Nerve fibre proliferation in interstitial cystitis,” Virchows Archiv A: Pathological Anatomy and Histopathology, vol. 416, no. 5, pp. 447–451, 1990. View at Google Scholar · View at Scopus
  53. H. T. Liu and H. C. Kuo, “Increased urine and serum nerve growth factor levels in interstitial cystitis suggest chronic inflammation is involved in the pathogenesis of disease,” PLoS ONE, vol. 7, no. 9, article e44687, 2012. View at Publisher · View at Google Scholar
  54. H.-T. Liu, C.-Y. Chen, and H.-C. Kuo, “Urinary nerve growth factor in women with overactive bladder syndrome,” BJU International, vol. 107, no. 5, pp. 799–803, 2011. View at Publisher · View at Google Scholar · View at Scopus
  55. M. A. Vizzard, “Changes in urinary bladder neurotrophic factor mRNA and NGF protein following urinary bladder dysfunction,” Experimental Neurology, vol. 161, no. 1, pp. 273–284, 2000. View at Publisher · View at Google Scholar · View at Scopus
  56. D. M. Daly, R. Chess-Williams, C. Chapple, and D. Grundy, “The inhibitory role of acetylcholine and muscarinic receptors in bladder afferent activity,” European Urology, vol. 58, no. 1, pp. 22–28, 2010. View at Publisher · View at Google Scholar · View at Scopus
  57. W. C. de Groat, “Highlights in basic autonomic neuroscience: contribution of the urothelium to sensory mechanisms in the urinary bladder,” Autonomic Neuroscience, vol. 177, no. 2, pp. 67–71, 2013. View at Publisher · View at Google Scholar
  58. Y.-C. Chuang, M. O. Fraser, Y. Yu, M. B. Chancellor, W. C. de Groat, and N. Yoshimura, “The role of bladder afferent pathways in bladder hyperactivity induced by the intravesical administration of nerve growth factor,” The Journal of Urology, vol. 165, no. 3, pp. 975–979, 2001. View at Google Scholar · View at Scopus
  59. L. Bueno and J. Fioramonti, “Effects of inflammatory mediators on gut sensitivity,” Canadian Journal of Gastroenterology, vol. 13, supplement A, pp. 42A–46A, 1999. View at Google Scholar · View at Scopus