Genome-Wide Uncovering of STAT3-Mediated miRNA Expression Profiles in Colorectal Cancer Cell Lines

Table 1

The most significantly differentially expressed known miRNAs in SW480/STAT3-siRNA.

miRNAID	log2(foldchange)^∗	Up-/down-expression	Adjusted 𝑃 value	Location
hsa-miR-934	10.81	up	2.80𝐸−62	chrX: 135633037–135633119
hsa-miR-1269a	8.00	up	1.95𝐸−09	chr4: 67142542–67142646
hsa-miR-671-5p	7.15	up	1.54𝐸−05	chr7: 150935507–150935624
hsa-miR-663a	7.00	up	4.72𝐸−05	chr20: 26188822–26188914
hsa-miR-1292	4.72	up	5.30𝐸−22	chr20: 2633423–2633488
hsa-miR-615-5p	4.55	up	8.00𝐸−56	chr12: 54427734–54427829
hsa-miR-2276	4.50	up	8.08𝐸−07	chr13: 24736555–24736643
hsa-miR-1307-3p	3.50	up	0.00𝐸+00	chr10: 105154010–105154158
hsa-miR-3654	3.11	up	6.82𝐸−08	chr7: 132719620–132719675
hsa-miR-4741	2.70	up	1.98𝐸−04	chr18: 20513312–20513401
hsa-miR-100-5p	2.53	up	7.79𝐸−04	chr11: 122022937–122023016
hsa-miR-3189-3p	2.53	up	1.23𝐸−06	chr19: 18497372–18497444
hsa-miR-548t-5p	2.51	up	6.42𝐸−12	chr4: 174189311–174189384
hsa-miR-769-3p	2.25	up	4.12𝐸−09	chr19: 46522190–46522307
hsa-miR-1307-5p	2.09	up	1.08𝐸−105	chr10: 105154010–105154158
hsa-miR-3687	2.05	up	3.22𝐸−04	chr21: 9826203–9826263
hsa-miR-324-5p	2.02	up	1.36𝐸−51	chr17: 7126616–7126698
hsa-miR-449c-5p	1.74	up	7.67𝐸−06	chr5: 54468090–54468181
hsa-miR-532-5p	1.51	up	3.50𝐸−16	chrX: 49767754–49767844
hsa-miR-122-5p	1.35	up	7.26𝐸−04	chr18: 56118306–56118390
hsa-miR-301b	1.30	up	1.84𝐸−03	chr22: 22007270–22007347
hsa-miR-652-3p	1.23	up	2.34𝐸−13	chrX: 109298557–109298654
hsa-miR-181a-5p	1.23	up	0.00𝐸+00	chr1: 198828173–198828282
hsa-miR-140-3p	1.18	up	0.00𝐸+00	chr16: 69966984–69967083
hsa-miR-331-3p	1.03	up	1.83𝐸−22	chr12: 95702196–95702289
hsa-miR-10a-5p	1.00	up	0.00𝐸+00	chr17: 46657200–46657309
hsa-miR-3656	−6.94	down	1.44𝐸−05	chr11: 118889654–118889722
hsa-miR-146a-5p	−4.58	down	2.48𝐸−06	chr5: 159912359–159912457
hsa-miR-1246	−3.64	down	3.18𝐸−292	chr2: 177465708–177465780
hsa-miR-143-3p	−3.50	down	3.27𝐸−05	chr5: 148808481–148808586
hsa-miR-23a-5p	−2.50	down	4.30𝐸−31	chr19: 13947401–13947473
hsa-miR-4508	−2.37	down	1.67𝐸−16	chr15: 23807209–23807278
hsa-miR-4488	−2.27	down	3.64𝐸−22	chr11: 61276068–61276129
hsa-miR-548o-3p	−2.09	down	2.26𝐸−03	chr7: 102046189–102046302
hsa-miR-29c-5p	−2.07	down	9.01𝐸−04	chr1: 207975197–207975284
hsa-miR-21-3p	−1.90	down	5.29𝐸−97	chr17: 57918627–57918698
hsa-miR-215	−1.85	down	0.00𝐸+00	chr1: 220291195–220291304
hsa-miR-139-3p	−1.64	down	3.27𝐸−11	chr11: 72326107–72326174
hsa-miR-720	−1.56	down	5.01𝐸−03	chr3: 164059129–164059238
hsa-miR-3141	−1.45	down	5.75𝐸−07	chr5: 153975572–153975632
hsa-miR-29b-1-5p	−1.43	down	2.20𝐸−07	chr7: 130562218–130562298
hsa-miR-141-5p	−1.41	down	9.27𝐸−03	chr12: 7073260–7073354
hsa-miR-25-5p	−1.29	down	0.00𝐸+00	chr7: 99691183–99691266
hsa-miR-197-5p	−1.27	down	1.24𝐸−08	chr1: 110141515–110141589
hsa-miR-1260b	−1.19	down	4.47𝐸−10	chr11: 96074602–96074690
hsa-miR-22-5p	−1.17	down	4.87𝐸−14	chr17: 1617197–1617281
hsa-miR-628-5p	−1.06	down	1.42𝐸−03	chr15: 55665138–55665232

Note: *fold change = (SW480/STAT3-siRNA)/( SW480/siRNA-control).