Genome-Wide Uncovering of STAT3-Mediated miRNA Expression Profiles in Colorectal Cancer Cell Lines

Table 4

The KEGG analysis of predicted targets mediated by more than 3 up-/downexpressed miRNAs.

Term	Pathway	Gene count	Percentage (%)	Bonferroni correction	Up-/down-expression
hsa05200	Pathways in cancer	264	2.05	4.44𝐸−10	up
hsa04360	Axon guidance	115	0.89	9.59𝐸−09	up
hsa04012	ErbB signaling pathway	78	0.61	1.30𝐸−05	up
hsa04510	Focal adhesion	161	1.25	2.95𝐸−05	up
hsa04910	Insulin signaling pathway	109	0.85	2.16𝐸−03	up
hsa05215	Prostate cancer	75	0.58	4.36𝐸−03	up
hsa05210	Colorectal cancer	71	0.55	6.27𝐸−03	up
hsa04310	Wnt signaling pathway	119	0.92	6.74𝐸−03	up
hsa05200	Pathways in cancer	226	2.20	9.67𝐸−09	down
hsa04510	Focal adhesion	143	1.39	2.27𝐸−06	down
hsa04020	Calcium signaling pathway	125	1.22	2.55𝐸−05	down
hsa05210	Colorectal cancer	66	0.64	1.37𝐸−04	down
hsa04144	Endocytosis	127	1.24	2.49𝐸−04	down
hsa04720	Long-term potentiation	55	0.54	2.85𝐸−04	down
hsa04360	Axon guidance	93	0.91	4.77𝐸−04	down
hsa05214	Glioma	50	0.49	2.58𝐸−03	down
hsa05220	Chronic myeloid leukemia	57	0.56	5.43𝐸−03	down
hsa04722	Neurotrophin signaling pathway	87	0.85	5.87𝐸−03	down
Hsa04012	ErbB signaling pathway	64	0.62	8.78𝐸−03	down