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BioMed Research International
Volume 2014, Article ID 191497, 4 pages
Research Article

Homocysteine Serum Levels in Diabetic Patients with Non Proliferative, Proliferative and without Retinopathy

1International Ph.D. programme in Neuropharmacology, University of Catania, 95123 Catania, Italy
2Department of Ophthalmology, University of Catania, 95123 Catania, Italy
3Research Center “The Great Senescence”, University of Catania, 95125 Catania, Italy
4Section of Pharmacology and Biochemistry, Department of Clinical and Molecular Biomedicine, University of Catania, Viale Andrea Doria 6, 95125 Catania, Italy
5IRCCS, Oasi Maria S.S.-Institute for Research on Mental Retardation and Brain Aging, 94018 Troina, Italy
6Department of Educational Sciences, University of Catania, Via Teatro Greco 84, 95124 Catania, Italy

Received 30 January 2014; Accepted 6 April 2014; Published 28 April 2014

Academic Editor: Maurizio Battaglia Parodi

Copyright © 2014 Giulia Malaguarnera et al. This is an open access article distributed under the Creative Commons Attribution License, which permits unrestricted use, distribution, and reproduction in any medium, provided the original work is properly cited.


Homocysteine has been associated with extracellular matrix changes. The diabetic retinopathy is a neurovascular complication of diabetes mellitus and it is the leading cause of vision loss among working adults worldwide. In this study, we evaluate the role of homocysteine in diabetic retinopathy analyzing the plasma levels of homocysteine in 63 diabetic type 2 patients with nonproliferative retinopathy (NPDR), 62 patients with proliferative diabetic retinopathy (PDR), 50 healthy subjects used as control group, and 75 randomly selected patients.