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BioMed Research International
Volume 2014, Article ID 191497, 4 pages
http://dx.doi.org/10.1155/2014/191497
Research Article

Homocysteine Serum Levels in Diabetic Patients with Non Proliferative, Proliferative and without Retinopathy

1International Ph.D. programme in Neuropharmacology, University of Catania, 95123 Catania, Italy
2Department of Ophthalmology, University of Catania, 95123 Catania, Italy
3Research Center “The Great Senescence”, University of Catania, 95125 Catania, Italy
4Section of Pharmacology and Biochemistry, Department of Clinical and Molecular Biomedicine, University of Catania, Viale Andrea Doria 6, 95125 Catania, Italy
5IRCCS, Oasi Maria S.S.-Institute for Research on Mental Retardation and Brain Aging, 94018 Troina, Italy
6Department of Educational Sciences, University of Catania, Via Teatro Greco 84, 95124 Catania, Italy

Received 30 January 2014; Accepted 6 April 2014; Published 28 April 2014

Academic Editor: Maurizio Battaglia Parodi

Copyright © 2014 Giulia Malaguarnera et al. This is an open access article distributed under the Creative Commons Attribution License, which permits unrestricted use, distribution, and reproduction in any medium, provided the original work is properly cited.

Linked References

  1. P. Hossain, B. Kawar, and M. El Nahas, “Obesity and diabetes in the developing world—a growing challenge,” The New England Journal of Medicine, vol. 356, no. 3, pp. 213–215, 2007. View at Publisher · View at Google Scholar · View at Scopus
  2. L. Rampello, I. Vecchio, G. Battaglia, G. Malaguarnera, and L. Rampello, “Diabetic neuropathy. Elements of epidemiology and pathophysiology,” Acta Medica Mediterranea, vol. 3, p. 219, 2012. View at Google Scholar
  3. S. M. Grundy, I. J. Benjamin, G. L. Burke et al., “Diabetes and cardiovascular disease: a statement for healthcare professionals from the american heart association,” Circulation, vol. 100, no. 10, pp. 1134–1146, 1999. View at Google Scholar · View at Scopus
  4. D. R. Matthews, I. M. Stratton, S. J. Aldington, R. R. Holman, and E. M. Kohner, “Risks of progression of retinopathy and vision loss related to tight blood pressure control in type 2 diabetes mellitus: UKPDS 69,” Archives of Ophthalmology, vol. 122, no. 11, pp. 1631–1640, 2004. View at Publisher · View at Google Scholar · View at Scopus
  5. G. Malaguarnera, C. Gagliano, C. Bucolo et al., “Lipoprotein(a) serum levels in diabetic patients with retinopathy,” BioMed Research International, vol. 2013, Article ID 943505, 5 pages, 2013. View at Publisher · View at Google Scholar
  6. M. Malaguarnera, R. Ferri, R. Bella, G. Alagona, A. Carnemolla, and G. Pennisi, “Homocysteine, vitamin B12 and folate in vascular dementia and in Alzheimer disease,” Clinical Chemistry and Laboratory Medicine, vol. 42, no. 9, pp. 1032–1035, 2004. View at Publisher · View at Google Scholar · View at Scopus
  7. M. Malaguarnera, G. Pistone, M. Motta et al., “Elevated plasma total homocysteine in centenarians,” Clinical Chemistry and Laboratory Medicine, vol. 42, no. 3, pp. 307–310, 2004. View at Publisher · View at Google Scholar · View at Scopus
  8. M. Dalton and J. S. Williams, “How best to approach point-of-care testing,” CAP Today, vol. 11, no. 12, pp. 46–50, 1997. View at Google Scholar · View at Scopus
  9. H. Wang, M. Yoshizumi, K. Lai et al., “Inhibition of growth and p21(ras) methylation in vascular endothelial cells by homocysteine but not cysteine,” Journal of Biological Chemistry, vol. 272, no. 40, pp. 25380–25385, 1997. View at Publisher · View at Google Scholar · View at Scopus
  10. J. Selhub, P. F. Jacques, A. G. Bostom et al., “Association between plasma homocysteine concentrations and extracranial carotid-artery stenosis,” The New England Journal of Medicine, vol. 332, no. 5, pp. 286–291, 1995. View at Publisher · View at Google Scholar · View at Scopus
  11. B. M. Coull, M. R. Malinow, N. Beamer, G. Sexton, F. Nordt, and P. De Garmo, “Elevated plasma homocyst(e)ine concentration as a possible independent risk factor for stroke,” Stroke, vol. 21, no. 4, pp. 572–576, 1990. View at Google Scholar · View at Scopus
  12. E. K. Hoogeveen, P. J. Kostense, P. E. D. Eysink et al., “Hyperhomocysteinemia is associated with the presence of retinopathy in type 2 diabetes mellitus: the Hoorn Study,” Archives of Internal Medicine, vol. 160, no. 19, pp. 2984–2990, 2000. View at Google Scholar · View at Scopus
  13. O. Aydemir, P. Türkçüoğlu, M. Güler et al., “Plasma and vitreous homocysteine concentrations in patients with proliferative diabetic retinopathy,” Retina, vol. 28, no. 5, pp. 741–743, 2008. View at Google Scholar
  14. M. Goldstein, I. Leibovitch, I. Yeffimov, S. Gavendo, B.-A. Sela, and A. Loewenstein, “Hyperhomocysteinemia in patients with diabetes mellitus with and without diabetic retinopathy,” Eye, vol. 18, no. 5, pp. 460–465, 2004. View at Publisher · View at Google Scholar · View at Scopus
  15. H. C. Cho, “The relationship among homocysteine, bilirubin, and diabetic retinopathy,” Diabetes & Metabolism, vol. 35, no. 6, pp. 595–601, 2011. View at Google Scholar
  16. G. N. Welch and J. Loscalzo, “Homocysteine and atherothrombosis,” The New England Journal of Medicine, vol. 338, no. 15, pp. 1042–1050, 1998. View at Publisher · View at Google Scholar · View at Scopus
  17. G. Marrazzo, P. Bosco, F. la Delia et al., “Neuroprotective effect of silibinin in diabetic mice,” Neuroscience Letters, vol. 504, no. 3, pp. 252–256, 2011. View at Publisher · View at Google Scholar · View at Scopus
  18. G. Marrazzo, I. Barbagallo, F. Galvano et al., “Role of dietary and endogenous antioxidants in diabetes,” Critical Reviews in Food Science and Nutrition, vol. 54, no. 12, pp. 1599–1616, 2014. View at Google Scholar