Nitric Oxide, Oxidative Stress, and Interplay in Diabetic Endothelial Dysfunction

Table 1

p66^Shc knockout mice phenotypes.

Disease	Phenotype	p66^Shc+/+	p66^Shc−/−
Diabetes	Peroxynitrite production	+++	+
	Lipid peroxidation	+++	+
	p66^Shc expression	++	−
Aging	NO availability	+	+++
	O2 production	+++	+
	Protein nitration	+++	+
	iNOS expression	+++	+
Hypercholesterolemia	Aortic lesions area	+++	+
	Plasmatic isoprostanes	+++	+
	Lipid peroxidation	+++	+
	Vascular apoptosis	+++	+

+++: high expression or production; ++: medium expression or production; +: moderate expression or production; −: no expression.