Table of Contents Author Guidelines Submit a Manuscript
BioMed Research International
Volume 2014 (2014), Article ID 194278, 8 pages
http://dx.doi.org/10.1155/2014/194278
Clinical Study

Transarterial Chemoembolization for the Treatment of Advanced Hepatocellular Carcinoma with Portal Vein Tumor Thrombosis: Prognostic Factors in a Single-Center Study of 188 Patients

1Department of Liver Diseases and Digestive Interventional Radiology, Xijing Hospital of Digestive Diseases, Xijing Hospital, Fourth Military Medical University, No. 15 West Changle Road, Xi’an 710032, China
2State Key Laboratory of Cancer Biology and Xijing Hospital of Digestive Diseases, Xijing Hospital, Fourth Military Medical University, Xi’an 710032, China

Received 15 September 2013; Revised 12 February 2014; Accepted 14 February 2014; Published 8 April 2014

Academic Editor: Qing He

Copyright © 2014 Lei Liu et al. This is an open access article distributed under the Creative Commons Attribution License, which permits unrestricted use, distribution, and reproduction in any medium, provided the original work is properly cited.

Linked References

  1. H. B. El-Serag, “Hepatocellular carcinoma,” New England Journal of Medicine, vol. 365, no. 12, pp. 1118–1127, 2011. View at Publisher · View at Google Scholar · View at Scopus
  2. A. Forner, J. M. Llovet, and J. Bruix, “Hepatocellular carcinoma,” The Lancet, vol. 379, no. 9822, pp. 1245–1255, 2012. View at Publisher · View at Google Scholar · View at Scopus
  3. European Association for the Study of the Liver and European Organisation for Research and Treatment of Cancer, “EASL-EORTC clinical practice guidelines: management of hepatocellular carcinoma,” Journal of Hepatology, vol. 56, no. 4, pp. 908–943, 2012. View at Publisher · View at Google Scholar
  4. J. Bruix and M. Sherman, “Management of hepatocellular carcinoma: an update,” Hepatology, vol. 53, no. 3, pp. 1020–1022, 2011. View at Publisher · View at Google Scholar · View at Scopus
  5. J. M. Llovet and J. Bruix, “Systematic review of randomized trials for unresectable hepatocellular carcinoma: chemoembolization improves survival,” Hepatology, vol. 37, no. 2, pp. 429–442, 2003. View at Publisher · View at Google Scholar · View at Scopus
  6. P. Tandon and G. Garcia-Tsao, “Prognostic indicators in hepatocellular carcinoma: a systematic review of 72 studies,” Liver International, vol. 29, no. 4, pp. 502–510, 2009. View at Publisher · View at Google Scholar · View at Scopus
  7. A. L. Cheng, Y. K. Kang, Z. Chen et al., “Efficacy and safety of sorafenib in patients in the Asia-Pacific region with advanced hepatocellular carcinoma: a phase III randomised, double-blind, placebo-controlled trial,” The Lancet Oncology, vol. 10, no. 1, pp. 25–34, 2009. View at Publisher · View at Google Scholar · View at Scopus
  8. J. M. Llovet, S. Ricci, V. Mazzaferro et al., “Sorafenib in advanced hepatocellular carcinoma,” New England Journal of Medicine, vol. 359, no. 4, pp. 378–390, 2008. View at Publisher · View at Google Scholar · View at Scopus
  9. M. Pinter, F. Hucke, I. Graziadei et al., “Advanced-stage hepatocellular carcinoma: transarterial chemoembolization versus sorafenib,” Radiology, vol. 263, no. 2, pp. 590–599, 2012. View at Publisher · View at Google Scholar
  10. G. E. Chung, J. Lee, H. Y. Kim et al., “Transarterial chemoembolization can be safely performed in patients with hepatocellular carcinoma invading the main portal vein and may improve the overall survival,” Radiology, vol. 258, no. 2, pp. 627–634, 2011. View at Publisher · View at Google Scholar · View at Scopus
  11. H. S. Lee, J. S. Kim, I. J. Choi, J. W. Chung, J. H. Park, and C. Y. Kim, “The safety and efficacy of transcatheter arterial chemoembolization in the treatment of patients with hepatocellular carcinoma and main portal vein obstruction. A prospective controlled study,” Cancer, vol. 79, no. 11, pp. 2087–2094, 1997. View at Google Scholar
  12. J. Luo, R. Guo, E. C. H. Lai et al., “Transarterial chemoembolization for unresectable hepatocellular carcinoma with portal vein tumor thrombosis: a prospective comparative study,” Annals of Surgical Oncology, vol. 18, no. 2, pp. 413–420, 2011. View at Publisher · View at Google Scholar · View at Scopus
  13. T. C. Xue, X. Y. Xie, L. Zhang, X. Yin, B. H. Zhang, and Z. G. Ren, “Transarterial chemoembolization for hepatocellular carcinoma with portal vein tumor thrombus: a meta-analysis,” BMC Gastroenterology, vol. 13, p. 60, 2013. View at Publisher · View at Google Scholar
  14. Y. Zhao, W. J. Wang, S. Guan et al., “Sorafenib combined with transarterial chemoembolization for the treatment of advanced hepatocellular carcinoma: a large-scale multicenter study of 222 patients,” Annals of Oncology, vol. 24, no. 7, pp. 1786–1792, 2013. View at Publisher · View at Google Scholar
  15. D. A. Leung, J. E. Goin, C. Sickles, B. J. Raskay, and M. C. Soulen, “Determinants of postembolization syndrome after hepatic chemoembolization,” Journal of Vascular and Interventional Radiology, vol. 12, no. 3, pp. 321–326, 2001. View at Google Scholar · View at Scopus
  16. T. Nakashima and M. Kojiro, “Pathologic characteristics of hepatocellular carcinoma,” Seminars in Liver Disease, vol. 6, no. 3, pp. 259–266, 1986. View at Google Scholar · View at Scopus
  17. J. W. Chung, J. H. Park, J. K. Han et al., “Hepatic tumors: predisposing factors for complications of transcatheter oily chemoembolization,” Radiology, vol. 198, no. 1, pp. 33–40, 1996. View at Google Scholar · View at Scopus
  18. M. Omata, L. A. Lesmana, R. Tateishi et al., “Asian pacific association for the study of the liver consensus recommendations on hepatocellular carcinoma,” Hepatology International, vol. 4, no. 2, pp. 439–474, 2010. View at Publisher · View at Google Scholar · View at Scopus
  19. C. S. Georgiades, K. Hong, M. D'Angelo, and J. H. Geschwind, “Safety and efficacy of transarterial chemoembolization in patients with unresectable hepatocellular carcinoma and portal vein thrombosis,” Journal of Vascular and Interventional Radiology, vol. 16, no. 12, pp. 1653–1659, 2005. View at Publisher · View at Google Scholar · View at Scopus
  20. K. M. Kim, J. H. Kim, I. S. Park et al., “Reappraisal of repeated transarterial chemoembolization in the treatment of hepatocellular carcinoma with portal vein invasion,” Journal of Gastroenterology and Hepatology, vol. 24, no. 5, pp. 806–814, 2009. View at Publisher · View at Google Scholar · View at Scopus
  21. J. H. Wang, C. S. Changchien, T. H. Hu et al., “The efficacy of treatment schedules according to Barcelona Clinic Liver Cancer staging for hepatocellular carcinoma-survival analysis of 3892 patients,” European Journal of Cancer, vol. 44, no. 7, pp. 1000–1006, 2008. View at Publisher · View at Google Scholar · View at Scopus
  22. Z. J. Niu, Y. L. Ma, P. Kang et al., “Transarterial chemoembolization compared with conservative treatment for advanced hepatocellular carcinoma with portal vein tumor thrombus: using a new classification,” Medical Oncology, vol. 29, no. 4, pp. 2992–2997, 2012. View at Publisher · View at Google Scholar · View at Scopus
  23. J. Ferlay, H. Shin, F. Bray, D. Forman, C. Mathers, and D. M. Parkin, “Estimates of worldwide burden of cancer in 2008: GLOBOCAN 2008,” International Journal of Cancer, vol. 127, no. 12, pp. 2893–2917, 2010. View at Publisher · View at Google Scholar · View at Scopus
  24. K. Takayasu, S. Arii, I. Ikai et al., “Prospective cohort study of transarterial chemoembolization for unresectable hepatocellular carcinoma in 8510 patients,” Gastroenterology, vol. 131, no. 2, pp. 461–469, 2006. View at Publisher · View at Google Scholar · View at Scopus