Table of Contents Author Guidelines Submit a Manuscript
BioMed Research International
Volume 2014, Article ID 204604, 6 pages
http://dx.doi.org/10.1155/2014/204604
Research Article

ATP during Early Bladder Stretch Is Important for Urgency in Detrusor Overactivity Patients

1Department of Urogynaecology, St George Hospital, University of New South Wales, Level 1, W.R. Pitney Building, Sydney, NSW 2217, Australia
2Graduate School of Medicine, University of Wollongong, Wollongong, NSW 2522, Australia
3Faculty of Health Sciences & Medicine, Bond University, Gold Coast, QLD 4229, Australia
4Department of Pharmacology, School of Medical Sciences, University of New South Wales, Sydney, NSW 2052, Australia

Received 28 February 2014; Revised 28 April 2014; Accepted 15 May 2014; Published 27 May 2014

Academic Editor: Michael Winder

Copyright © 2014 Y. Cheng et al. This is an open access article distributed under the Creative Commons Attribution License, which permits unrestricted use, distribution, and reproduction in any medium, provided the original work is properly cited.

Linked References

  1. L. A. Birder, A. J. Kanai, F. Cruz, K. Moore, and C. H. Fry, “Is the urothelium intelligent?” Neurourology and Urodynamics, vol. 29, no. 4, pp. 598–602, 2010. View at Publisher · View at Google Scholar · View at Scopus
  2. G. Burnstock, “Purinergic nerves,” Pharmacological Reviews, vol. 24, no. 3, pp. 509–581, 1972. View at Google Scholar · View at Scopus
  3. Y. Cheng, K. J. Mansfield, S. L. Sandow, P. Sadananda, E. Burcher, and K. H. Moore, “Porcine bladder urothelial, myofibroblast, and detrusor muscle cells: characterization and ATP release,” Frontiers in Pharmacology, vol. 2, article 27, 2011. View at Publisher · View at Google Scholar · View at Scopus
  4. D. R. Ferguson, I. Kennedy, and T. J. Burton, “ATP is released from rabbit urinary bladder epithelial cells by hydrostatic pressure changes—a possible sensory mechanism?” Journal of Physiology, vol. 505, no. 2, pp. 503–511, 1997. View at Publisher · View at Google Scholar · View at Scopus
  5. P. Sadananda, F. Shang, L. Liu, K. J. Mansfield, and E. Burcher, “Release of ATP from rat urinary bladder mucosa: role of acid, vanilloids and stretch,” The British Journal of Pharmacology, vol. 158, no. 7, pp. 1655–1662, 2009. View at Publisher · View at Google Scholar · View at Scopus
  6. V. Kumar, C. C. Chapple, and R. Chess-Williams, “Characteristics of adenosine triphosphatase release from porcine and human normal bladder,” Journal of Urology, vol. 172, no. 2, pp. 744–747, 2004. View at Publisher · View at Google Scholar · View at Scopus
  7. J. Nishiguchi, Y. Hayashi, M. B. Chancellor et al., “Detrusor overactivity induced by intravesical application of adenosine 5′-triphosphate under different delivery conditions in rats,” Urology, vol. 66, no. 6, pp. 1332–1337, 2005. View at Publisher · View at Google Scholar · View at Scopus
  8. L. Birder and K.-E. Andersson, “Urothelial signaling,” Physiological Reviews, vol. 93, no. 2, pp. 653–680, 2013. View at Publisher · View at Google Scholar · View at Scopus
  9. D. A. Cockayne, S. G. Hamilton, Q. M. Zhu et al., “Urinary bladder hyporeflexia and reduced pain-related behaviour in P2X3-deficient mice,” Nature, vol. 407, no. 6807, pp. 1011–1015, 2000. View at Publisher · View at Google Scholar · View at Scopus
  10. C. Wu, G. P. Sui, and C. H. Fry, “Purinergic regulation of guinea pig suburothelial myofibroblasts,” Journal of Physiology, vol. 559, no. 1, pp. 231–243, 2004. View at Publisher · View at Google Scholar · View at Scopus
  11. V. Kumar, C. R. Chapple, A. M. Surprenant, and R. Chess-Williams, “Enhanced adenosine triphosphate release from the urothelium of patients with painful bladder syndrome: a possible pathophysiological explanation,” Journal of Urology, vol. 178, no. 4, pp. 1533–1536, 2007. View at Publisher · View at Google Scholar · View at Scopus
  12. V. Kumar, C. R. Chapple, D. Rosario, P. R. Tophill, and R. Chess-Williams, “In vitro release of adenosine triphosphate from the urothelium of human bladders with detrusor overactivity, both neurogenic and idiopathic,” European Urology, vol. 57, no. 6, pp. 1087–1092, 2010. View at Publisher · View at Google Scholar · View at Scopus
  13. Y. Cheng, K. J. Mansfield, W. Allen, C. A. Walsh, E. Burcher, and K. H. Moore, “Does adenosine triphosphate released into voided urodynamic fluid contribute to urgency signaling in women with bladder dysfunction?” Journal of Urology, vol. 183, no. 3, pp. 1082–1086, 2010. View at Publisher · View at Google Scholar · View at Scopus
  14. Y. Cheng, K. J. Mansfield, W. Allen, R. J. Millard, E. Burcher, and K. H. Moore, “Correlation between cystometric volumes, ATP release, and pH in women with overactive bladder versus controls,” Neurourology and Urodynamics, vol. 32, no. 7, pp. 969–973, 2013. View at Publisher · View at Google Scholar · View at Scopus
  15. M. Vlaskovska, L. Kasakov, W. Rong et al., “P2X3 knock-out mice reveal a major sensory role for urothelially released ATP,” Journal of Neuroscience, vol. 21, no. 15, pp. 5670–5677, 2001. View at Google Scholar · View at Scopus
  16. P. Abrams, L. Cardozo, M. Fall et al., “The standardisation of terminology of lower urinary tract function: report from the standardisation sub-committee of the international continence society,” Neurourology and Urodynamics, vol. 21, no. 2, pp. 167–178, 2002. View at Publisher · View at Google Scholar · View at Scopus
  17. W. Yu, S. C. Robson, and W. G. Hill, “Expression and distribution of ectonucleotidases in mouse urinary bladder,” PLoS ONE, vol. 6, no. 4, Article ID e18704, 2011. View at Publisher · View at Google Scholar · View at Scopus
  18. R. A. Harvey, D. E. Skennerton, D. Newgreen, and C. H. Fry, “The contractile potency of adenosine triphosphate and ecto-adenosine triphosphatase activity in guinea pig detrusor and detrusor from patients with a stable, unstable or obstructed bladder,” Journal of Urology, vol. 168, no. 3, pp. 1235–1239, 2002. View at Google Scholar · View at Scopus
  19. G. Burnstock, “Therapeutic potential of purinergic signalling for diseases of the urinary tract,” BJU International, vol. 107, no. 2, pp. 192–204, 2011. View at Publisher · View at Google Scholar · View at Scopus
  20. J. Southgate, C. L. Varley, M. A. Garthwaite et al., “Differentiation potential of urothelium from patients with benign bladder dysfunction,” BJU International, vol. 99, no. 6, pp. 1506–1516, 2007. View at Publisher · View at Google Scholar · View at Scopus