Thymic Epithelial Cell Development and Its Dysfunction in Human Diseases

Table 4

Models of Aire regulate TRAs expression.

Model	Classical transcription factor	Random transcriptional activator	Epigenetic tag recognition
Manner	Bind to promoter of target genes initiating the transcription of master transcription factors	Loosening the chromatin structure	Bind modified histones
Evidence	DNA binding domain activating transcription; Recruit transcriptional molecules	DNA accessibility function; DNA sequences recognition	Demethylation histone 3 interact with transcription cofactors