Research Article

Expression of Phosphocitrate-Targeted Genes in Osteoarthritis Menisci

Table 3

Genes classified in skeletal development, steroid biosynthetic process, and DNA repair.

Biological processGene nameGene IDDiffer expre (fold)*Description

Skeletal development
COL2A1X0626821.29Collagen, type II, alpha 1
COL11A1J041779.86Collagen, type XI, alpha 1
COL1A1AI7436212.59Collagen, type I, alpha 1
ACANNM_001135 9.17Aggrecan
POSTNAW1371485.57Periostin, osteoblast specific factor
PAX1AA7250784.73Paired box 1
FRZBU919033.22Frizzled-related protein
MMP9NM_0049942.58Matrix metallopeptidase 9
GLI2NM_0303792.54GLI-Kruppel family member GLI2
FGFR3NM_0001422.40Fibroblast growth factor receptor 3
FGF18AI7988632.33Fibroblast growth factor 18
TGFB2NM_0032382.36Transforming growth factor, beta 2
TRPS1AK0009482.32Trichorhinophalangeal syndrome I
RUNX2AW4695462.24Runt-related transcription factor 2
PRELPU413442.15Proline/arginine-rich end leucine-rich repeat protein
PAPSS2AW2999582.033-phosphoadenosine 5-phosphosulfate synthase 2
SOX9NM_0003462.00SRY (sex determining region Y)-box 9
MEPENM_020203−13.5Matrix, extracellular phosphoglycoprotein with ASARM motif
PTHLHBC005961−6.79Parathyroid hormone-like hormone
CHRDL2AF332891−6.20Chordin-like 2
COL10AX98568−5.40collagen, type X, alpha 1 (Schmid metaphyseal chondrodysplasia)
BMP6NM_001718−4.48Bone morphogenetic protein 6
GDF10NM_004962−2.99Growth differentiation factor 10
BMP8BAA610122−2.70Bone morphogenetic protein 8b
TGFBR2NM_003242−2.35Transforming growth factor, beta receptor II (70/80 kDa)
IGFBP4NM_001552−2.30Insulin-like growth factor binding protein 4
Steroid biosynthetic process
SQLEAA6397053.81Squalene epoxidase
SRD5A1NM_0010473.75Steroid-5-alpha-reductase, alpha polypeptide 1
FDXRNM_0041103.26Ferredoxin reductase
HMGCS1NM_0021303.123-hydroxy-3-methylglutaryl-Coenzyme A synthase 1 (soluble)
HMGCRAL5186272.153-hydroxy-3-methylglutaryl-Coenzyme A reductase
LSSD638073.04Lanosterol synthase (2,3-oxidosqualene-lanosterol cyclase)
DHCR24NM_0147622.6624-dehydrocholesterol reductase
DHCR7NM_0013602.577-dehydrocholesterol reductase
OPRS1NM_0058662.62Opioid receptor, sigma 1
CYB5R2NM_0162292.37Cytochrome b5 reductase 2
SC5DD851812.06Sterol-C5-desaturase
BMP6NM_001718−4.48Bone morphogenetic protein 6
CYP39A1NM_016593−2.21Cytochrome P450, family 39, subfamily A, polypeptide 1
HSD3B7BC004929−2.103 beta-hydroxysteroid dehydrogenase type 7
ADMNM_001124−2.06Adrenomedullin
ABCG1NM_004915−2.04ATP-binding cassette, sub-family G (WHITE), member 1
DNA repair
TOP2AAU1599423.75Topoisomerase (DNA) II alpha 170 kDa
RAD52BAF1259492.83RAD52 homolog (S. cerevisiae)
RAD54B NM_0124152.05RAD54 homolog B (S. cerevisiae)
TYMSNM_0010712.40Thymidylate synthetase
RFC5BG2606582.39Replication factor C (activator 1) 5, 36.5 kDa
SOD2AL050388−9.58Superoxide dismutase 2, mitochondrial
REV3LNM_002912−3.08REV3-like, catalytic subunit of DNA polymerase zeta (yeast)

Negative number indicates decreased expression and positive number indicates increased expression (fold change).