Research Article

Prevalence of Gene Rearrangements in Mexican Children with Acute Lymphoblastic Leukemia: A Population Study—Report from the Mexican Interinstitutional Group for the Identification of the Causes of Childhood Leukemia

Table 2

Proportions of the four molecular subgroups reported in the present study, other Mexican studies, and studies from other countries.

Author, year of publication [Reference]CountryNumber of patientsETV6-RUNX1
(%)
TCF3-PBX1
(%)
MLL rearrangements 
(%)
BCR-ABL1
(%)

MIGICCL study, 2014 [present study]Mexico City28724 (7.4)20 (7.1)4 (1.4)5 (1.8)
Other Mexican studies
 Pérez-Vera et al., 2008 [4]Mexico City595 (8.7)5 (8.7)1 (1.7)
 Jiménez-Morales et al., 2008 [5]Mexico City537 (13.5)6 (11.5)2 (3.8)
 Daniel-Cravioto et al., 2009 [6]Mexico City261 (3.8)17 (65.4)1 (3.8)
Studies from other countries
 Amor et al., 1998 [11]Australia6622 (33.0)
 Zuna et al., 1999 [12]Czech Republic19041 (21.6)
 Codrington et al., 2000 [13]England5622 (39.0)
 Siraj et al., 2003 [14]India25918 (7.0)18 (7.0)2 (4)*14 (5.0)
 Mesquita et al., 2003 [15]Brazil8810 (11.4)5 (5.7)1 (1.1)1 (1.1)
 Pui et al., 2003 [16]
  White childrenUSA33864 (18.9)10 (3.0)10 (3.0)8 (2.4)
  Black childrenUSA689 (13.2)8 (11.8)1 (1.5)4 (5.9)
 Aldrich et al., 2006 [17]
  Non-Hispanic WhiteUSA14034 (24.3)6 (4.3)4 (2.9)1 (0.7)
  HispanicUSA15119 (12.6)7 (4.6)3 (2.0)2 (1.3)
 Lazic et al., 2010 [18]Serbia7012 (17.1)6 (8.6)07 (10.0)
 Alonso et al., 2012 [19]Argentina38049 (12.9)19 (5.0)40 (10.5)6 (1.6)

MIGICCL: Mexican Interinstitutional Group for the Identification of the Causes of Childhood Leukemia.
— Not screened.
*Other MLL rearrangements were detected in two (4%) of 50 samples analyzed by Southern blot.