The Soluble Form of CTLA-4 from Serum of Patients with Autoimmune Diseases Regulates T-Cell Responses
sCTLA-4 from autoimmune sera is able to increase the secretion of inhibitory cytokines. We show the ability of sCTLA-4 contained in the sera of autoimmune patients to increase the secretion of transforming growth factor-β (TGF-β) and Interleukin-10 (IL-10). Positive or negative sera are indicated by an alphanumeric code followed by and , respectively. CTLA-4 Ig fusion protein is a positive control of secretion of cytokines. The concentration of inhibitory cytokines is expressed in ng/mL. The data represent the averages standard deviations (error bars) of double samples. A representative experiment out three is shown.