Table of Contents Author Guidelines Submit a Manuscript
BioMed Research International
Volume 2014 (2014), Article ID 217078, 15 pages
Research Article

ECM Inspired Coating of Embroidered 3D Scaffolds Enhances Calvaria Bone Regeneration

1Department of Trauma and Reconstructive Surgery, University Hospital Carl Gustav Carus, Technische Universität Dresden, Fetscherstraße 74, 01307 Dresden, Germany
2Centre for Translational Bone, Joint and Soft Tissue Research, University Hospital and Medical Faculty, Technische Universität Dresden, Fetscherstraße 74, 01307 Dresden, Germany
3Catgut GmbH, Gewerbepark 18, 08258 Markneukirchen, Germany
4Max Bergmann Center of Biomaterials, Budapester Straße 27, 01069 Dresden, Germany
5DFG-Center for Regenerative Therapies Dresden (CRTD), Fetscherstraße 105, 01307 Dresden, Germany

Received 6 November 2013; Revised 27 March 2014; Accepted 11 April 2014; Published 11 June 2014

Academic Editor: Yin Xiao

Copyright © 2014 C. Rentsch et al. This is an open access article distributed under the Creative Commons Attribution License, which permits unrestricted use, distribution, and reproduction in any medium, provided the original work is properly cited.


Resorbable polymeric implants and surface coatings are an emerging technology to treat bone defects and increase bone formation. This approach is of special interest in anatomical regions like the calvaria since adults lose the capacity to heal large calvarial defects. The present study assesses the potential of extracellular matrix inspired, embroidered polycaprolactone-co-lactide (PCL) scaffolds for the treatment of 13 mm full thickness calvarial bone defects in rabbits. Moreover the influence of a collagen/chondroitin sulfate (coll I/cs) coating of PCL scaffolds was evaluated. Defect areas filled with autologous bone and empty defects served as reference. The healing process was monitored over 6 months by combining a novel ultrasonographic method, radiographic imaging, biomechanical testing, and histology. The PCL coll I/cs treated group reached 68% new bone volume compared to the autologous group (100%) and the biomechanical stability of the defect area was similar to that of the gold standard. Histological investigations revealed a significantly more homogenous bone distribution over the whole defect area in the PCL coll I/cs group compared to the noncoated group. The bioactive, coll I/cs coated, highly porous, 3-dimensional PCL scaffold acted as a guide rail for new skull bone formation along and into the implant.