Transferrin-Conjugated SNALPs Encapsulating 2′-O-Methylated miR-34a for the Treatment of Multiple Myeloma

Table 1

Mean diameter, polydispersity index, and zeta potential of the different SNALPs-based formulations.

Formulations	miRNA chemistry	Targeting ligand	Mean diameter (nm) ± SD	PI ± SD	ZP (mV) ± SD
SNALP1	Wild type	—	157.18±17.18	0.16±0.03	−13.52±2.28
SNALP2	OMet	—	127.75±10.68	0.25±0.03	−5.19±5.38
Tf-SNALP1	Wild type	Tf	158.32±10.25	0.14±0.05	−23.62±1.54
Tf-SNALP2	OMet	Tf	130.84±8.41	0.21±0.02	−18.13±4.39