Table of Contents Author Guidelines Submit a Manuscript
BioMed Research International
Volume 2014, Article ID 217865, 11 pages
http://dx.doi.org/10.1155/2014/217865
Research Article

Activity Exerted by a Testosterone Derivative on Myocardial Injury Using an Ischemia/Reperfusion Model

1Laboratory of Pharmaco-Chemistry, Faculty of Chemical Biological Sciences, University Autonomous of Campeche, Avenida Agustín Melgar s/n, Colonia Buenavista, 24039 San Francisco de Campeche, CAM, Mexico
2Escuela Nacional de Ciencias Biológicas del Instituto Politéecnico Nacional, Prolongación de Carpio y Plan de Ayala s/n, Col. Santo Tomas, 11340 Mexico City, DF, Mexico
3Facultad de Nutrición, Médicos y Odontologos s/n, Unidad del Bosque, 91010 Xalapa, VER, Mexico
4Faculty of Medicine, University Autonomous of Campeche, Avenida Patricio Trueba de Regil s/n, Col Lindavista, 24090 San Francisco de Campeche, CAM, Mexico

Received 19 January 2014; Revised 4 March 2014; Accepted 5 March 2014; Published 16 April 2014

Academic Editor: Joen-Rong Sheu

Copyright © 2014 Figueroa-Valverde Lauro et al. This is an open access article distributed under the Creative Commons Attribution License, which permits unrestricted use, distribution, and reproduction in any medium, provided the original work is properly cited.

Linked References

  1. S. Yusuf, S. Hawken, and S. Ounpuu, “Effect of potentially modifiable risk factors associated with myocardial infarction in 52 countries (the INTERHEART study): case-control study,” The Lancet, vol. 366, no. 9497, pp. 1640–1649, 2005. View at Publisher · View at Google Scholar
  2. K. Thygesen, J. S. Alpert, and H. D. White, “Universal definition of myocardial infarction,” Journal of the American College of Cardiology, vol. 50, no. 22, pp. 2173–2195, 2007. View at Publisher · View at Google Scholar · View at Scopus
  3. M. A. Pfeffer, “Left ventricular remodeling after acute myocardial infarction,” Annual Review of Medicine, vol. 46, pp. 455–466, 1995. View at Publisher · View at Google Scholar · View at Scopus
  4. P. Zhai, T. E. Eurell, R. Cotthaus, E. H. Jeffery, J. M. Bahr, and D. R. Gross, “Effect of estrogen on global myocardial ischemia-reperfusion injury in female rats,” The American Journal of Physiology—Heart and Circulatory Physiology, vol. 279, no. 6, pp. H2766–H2775, 2000. View at Google Scholar · View at Scopus
  5. H. Yadav, M. Singhg, P. Sharma, D. Mittal, T. Behl, and A. Pal, “Possible role of cyclooxygenase-2 in remote aortic preconditioning induced cardioprotection in rat heart,” Pharmacologia, vol. 3, no. 1, pp. 1–8, 2012. View at Publisher · View at Google Scholar
  6. K. Shinmura, R. Bolli, S. Liu et al., “Aldose reductase is an obligatory mediator of the late phase of ischemic preconditioning,” Circulation Research, vol. 91, no. 3, pp. 240–246, 2002. View at Publisher · View at Google Scholar · View at Scopus
  7. L. Calabresi, G. Rossoni, M. Gomaraschi, F. Sisto, F. Berti, and G. Franceschini, “High-density lipoproteins protect isolated rat hearts from ischemia-reperfusion injury by reducing cardiac tumor necrosis factor-α content and enhancing prostaglandin release,” Circulation Research, vol. 92, no. 3, pp. 330–337, 2003. View at Publisher · View at Google Scholar · View at Scopus
  8. M. G. W. Camitta, S. A. Gabel, P. Chulada et al., “Cyclooxygenase-1 and -2 knockout mice demonstrate increased cardiac ischemia/reperfusion injury but are protected by acute preconditioning,” Circulation, vol. 104, no. 20, pp. 2453–2458, 2001. View at Google Scholar · View at Scopus
  9. R. Bolli, K. Shinmura, X. Tang et al., “Discovery of a new function of cyclooxygenase (COX)-2: COX-2 is a cardioprotective protein that alleviates ischemia/reperfusion injury and mediates the late phase of preconditioning,” Cardiovascular Research, vol. 55, no. 3, pp. 506–519, 2002. View at Publisher · View at Google Scholar · View at Scopus
  10. L. Khalaj, H. Peirovi, F. Khodagholi, A. Abdi, L. Dargahi, and A. Ahmadiani, “Acute 17β-estradiol pretreatment protects against abdominal aortic occlusion induced spinal cord ischemic-reperfusion injury,” Neurochemical Research, vol. 36, no. 2, pp. 268–280.
  11. X. Song, G. Li, J. Vaage, and G. Valen, “Effects of sex, gonadectomy, and oestrogen substitution on ischaemic preconditioning and ischaemia-reperfusion injury in mice,” Acta Physiologica Scandinavica, vol. 177, no. 4, pp. 459–466, 2003. View at Publisher · View at Google Scholar · View at Scopus
  12. M. A. Cavasin, S. S. Sankey, A. Yu, S. Menon, and X. Yang, “Estrogen and testosterone have opposing effects on chronic cardiac remodeling and function in mice with myocardial infarction,” The American Journal of Physiology—Heart and Circulatory Physiology, vol. 284, no. 5, pp. H1560–H1569, 2003. View at Google Scholar · View at Scopus
  13. J. W. Horton, D. J. White, and D. L. Maass, “Gender-related differences in myocardial inflammatory and contractile responses to major burn trauma,” The American Journal of Physiology—Heart and Circulatory Physiology, vol. 286, no. 1, pp. H202–H213, 2004. View at Google Scholar · View at Scopus
  14. E. A. Booth, R. R. Flint, K. L. Lucas, A. K. Knittel, and B. R. Lucchesi, “Estrogen protects the heart from ischemia-reperfusion injury via COX-2-derived PGI2,” Journal of Cardiovascular Pharmacology, vol. 52, no. 3, pp. 228–235, 2008. View at Publisher · View at Google Scholar · View at Scopus
  15. F. Callies, H. Strömer, R. H. G. Schwinger et al., “Administration of testosterone is associated with a reduced susceptibility to myocardial ischemia,” Endocrinology, vol. 144, no. 10, pp. 4478–4483, 2003. View at Publisher · View at Google Scholar · View at Scopus
  16. M. Wang, Y. Wang, A. Abarbanell et al., “Both endogenous and exogenous testosterone decrease myocardial STAT3 activation and SOCS3 expression after acute ischemia and reperfusion,” Surgery, vol. 146, no. 2, pp. 138–144, 2009. View at Publisher · View at Google Scholar · View at Scopus
  17. C. Huang, H. Gu, W. Zhang, J. L. Herrmann, and M. Wang, “Testosterone-down-regulated akt pathway during cardiac ischemia/reperfusion: a mechanism involving BAD, Bcl-2 and FOXO3a,” Journal of Surgical Research, vol. 164, no. 1, pp. e1–e11, 2010. View at Publisher · View at Google Scholar · View at Scopus
  18. D. E. Remmers, W. G. Cioffi, K. I. Bland, P. Wang, M. K. Angele, and I. H. Chaudry, “Testosterone: the crucial hormone responsible for depressing myocardial function in males after trauma-hemorrhage,” Annals of Surgery, vol. 227, no. 6, pp. 790–799, 1998. View at Publisher · View at Google Scholar · View at Scopus
  19. D. E. Remmers, P. Wang, W. G. Cioffi, K. I. Bland, and I. H. Chaudry, “Testosterone receptor blockade after trauma-hemorrhage improves cardiac and hepatic functions in males,” The American Journal of Physiology—Heart and Circulatory Physiology, vol. 273, no. 6, pp. H2919–H2925, 1997. View at Google Scholar · View at Scopus
  20. E. F. du Toit, E. Rossouw, J. van Rooyen, and A. Lochner, “Proposed mechanisms for the anabolic steroid-induced increase in myocardial susceptibility to ischaemia/reperfusion injury,” Cardiovascular Journal of South Africa, vol. 16, no. 1, pp. 21–28, 2005. View at Google Scholar · View at Scopus
  21. A. Vannay, A. Fekete, R. Langer et al., “Dehydroepiandrosterone pretreatment alters the ischaemia/reperfusion-induced VEGF, IL-1 and IL-6 gene expression in acute renal failure,” Kidney and Blood Pressure Research, vol. 32, no. 3, pp. 175–184, 2009. View at Publisher · View at Google Scholar · View at Scopus
  22. J. Simard, I. Luthy, J. Guay, A. Bélanger, and F. Labrie, “Characteristics of interaction of the antiandrogen flutamide with the androgen receptor in various target tissues,” Molecular and Cellular Endocrinology, vol. 44, no. 3, pp. 261–270, 1986. View at Google Scholar · View at Scopus
  23. R. M. Graham, H. F. Oates, L. M. Stoker, and G. S. Stokes, “Alpha blocking action of the antihypertensive agent, prazosin,” Journal of Pharmacology and Experimental Therapeutics, vol. 201, no. 3, pp. 747–752, 1977. View at Google Scholar · View at Scopus
  24. C. Bengtsson, G. Johnsson, and C. G. Regardh, “Plasma levels and effects of metoprolol on blood pressure and heart rate in hypertensive patients after an acute dose and between two doses during long term treatment,” Clinical Pharmacology and Therapeutics, vol. 17, no. 4, pp. 400–408, 1975. View at Google Scholar · View at Scopus
  25. P. D. Henry, “Comparative pharmacology of calcium antagonists: nifedipine, verapamil and diltiazem,” The American Journal of Cardiology, vol. 46, no. 6, pp. 1047–1058, 1980. View at Google Scholar · View at Scopus
  26. T. L. Owen, I. C. Ehrhart, W. J. Weidner, J. B. Scott, and F. J. Haddy, “Effects of indomethacin on local blood flow regulation in canine heart and kidney,” Proceedings of the Society for Experimental Biology and Medicine, vol. 149, no. 4, pp. 871–876, 1975. View at Google Scholar · View at Scopus
  27. S. E. Burke, A. M. Lefer, K. C. Nicolaou, G. M. Smith, and J. B. Smith, “Responsiveness of platelets and coronary arteries from different species to synthetic thromboxane and prostaglandin endoperoxide analogues,” The British Journal of Pharmacology, vol. 78, no. 2, pp. 287–292, 1983. View at Google Scholar · View at Scopus
  28. K. Bayne, “Revised guide for the care and use of laboratory animals available. American physiological society,” The Physiologist, vol. 39, no. 4, pp. 199–211, 1996. View at Google Scholar · View at Scopus
  29. E. A. Booth, N. R. Obeid, and B. R. Lucchesi, “Activation of estrogen receptor-α protects the in vivo rabbit heart from ischemia-reperfusion injury,” The American Journal of Physiology—Heart and Circulatory Physiology, vol. 289, no. 5, pp. H2039–H2047, 2005. View at Publisher · View at Google Scholar · View at Scopus
  30. C. Hocht, L. Opezzo, S. Gorzalczany, G. Bramuglia, and C. Tiara, “Una aproximación cinética y dinámica de metildopa en ratas con coartación aórtica mediante microdiálisis,” Revista Argentina de Cardiologia, vol. 67, pp. 769–773, 1999. View at Google Scholar
  31. M. E. Herr and F. W. Heyl, “‘Enamine’ derivatives of steroidal carbonyl compounds. III. The synthesis of C11-oxygenated testosterones,” Journal of the American Chemical Society, vol. 75, no. 23, pp. 5927–5930, 1953. View at Publisher · View at Google Scholar
  32. D. E. Stevenson, J. N. Wright, and M. Akhtar, “Synthesis of 19-functionalised derivatives of 16α-hydroxy-testosterone: mechanistic studies on oestriol biosynthesis,” Journal of the Chemical Society—Chemical Communications, vol. 16, pp. 1078–1080, 1985. View at Google Scholar · View at Scopus
  33. A. K. Shirayev, I. K. Moiseev, and S. S. Karpeev, “Synthesis and cis/trans isomerism of N-alkyl-1,3-oxathiolane-2-imines,” Arkivoc, vol. 2005, no. 4, pp. 199–207, 2005. View at Google Scholar · View at Scopus
  34. D. J. Uppiah, M. G. Bhowon, and S. J. Laulloo, “Solventless synthesis of imines derived from diphenyldisulphide diamine or p-Vanillin,” E-Journal of Chemistry, vol. 6, no. 1, pp. S195–S200, 2009. View at Publisher · View at Google Scholar · View at Scopus
  35. D. Bouïs, G. A. P. Hospers, C. Meijer, G. Molema, and N. H. Mulder, “Endothelium in vitro: a review of human vascular endothelial cell lines for blood vessel-related research,” Angiogenesis, vol. 4, no. 2, pp. 91–102, 2001. View at Publisher · View at Google Scholar · View at Scopus
  36. S. Beer, M. Reincke, M. Kral et al., “Susceptibility to cardiac ischemia/reperfusion injury is modulated by chronic estrogen status,” Journal of Cardiovascular Pharmacology, vol. 40, no. 3, pp. 420–428, 2002. View at Publisher · View at Google Scholar · View at Scopus
  37. L. Figueroa-Valverde, F. Díaz-Cedillo, M. López-Ramos, E. García-Cervera, and K. Quijano-Ascencio, “Inotropic activity induced by carbamazepine-alkyne derivative in an isolated heart model and perfused to constant flow,” Biomedica, vol. 31, no. 2, pp. 232–241, 2011. View at Google Scholar · View at Scopus
  38. L. Figueroa-Valverde, H. Luna, C. Castillo-Henkel, O. Muñoz-Garcia, T. Morato-Cartagena, and G. Ceballos-Reyes, “Synthesis and evaluation of the cardiovascular effects of two, membrane impermeant, macromolecular complexes of dextran-testosterone,” Steroids, vol. 67, no. 7, pp. 611–619, 2002. View at Publisher · View at Google Scholar · View at Scopus
  39. S. J. Hutchison, A. E. M. Browne, E. Ko et al., “Dehydroepiandrosterone sulfate induces acute vasodilation of porcine coronary arteries in vitro and in vivo,” Journal of Cardiovascular Pharmacology, vol. 46, no. 3, pp. 325–332, 2005. View at Publisher · View at Google Scholar · View at Scopus
  40. J. Tan, Y. Sharief, K. G. Hamil et al., “Dehydroepiandrosterone activates mutant androgen receptors expressed in the androgen-dependent human prostate cancer xenograft CWR22 and LNCaP cells,” Molecular Endocrinology, vol. 11, no. 4, pp. 450–459, 1997. View at Publisher · View at Google Scholar · View at Scopus
  41. J. J. Lilley, J. Golden, and R. A. Stone, “Adrenergic regulation of blood pressure in chronic renal failure,” Journal of Clinical Investigation, vol. 57, no. 5, pp. 1190–1200, 1976. View at Google Scholar · View at Scopus
  42. L. Figueroa-Valverde, F. Díaz-Cedillo, E. García-Cervera et al., “Positive inotropic activity induced by a dehydroisoandrosterone derivative in isolated rat heart model,” Archives of Pharmacal Research, vol. 36, no. 10, pp. 1270–1278, 2013. View at Publisher · View at Google Scholar
  43. C. Seillan, C. Ody, F. Russo-Marie, and D. Duval, “Differential of sex steroids of prostaglandin secretion by male and female cultured piglet endothelial cells,” Prostaglandins, vol. 26, no. 1, pp. 3–12, 1983. View at Google Scholar · View at Scopus
  44. Y. Yokoyama, H. Xu, N. Kresge et al., “Role of thromboxane A2 in early BDL-induced portal hypertension,” The American Journal of Physiology—Gastrointestinal and Liver Physiology, vol. 284, no. 3, pp. G453–G460, 2003. View at Google Scholar · View at Scopus
  45. P. D. Hirsh, L. D. Hillis, W. B. Campbell, B. G. Firth, and J. T. Willerson, “Release of prostaglandins and thromboxane into the coronary circulation in patients with ischemic heart disease,” The New England Journal of Medicine, vol. 304, no. 12, pp. 685–691, 1981. View at Google Scholar · View at Scopus