Table 4: Adjusted odds ratio (AOR) and 95% confidence interval (CI) of clinical status and CD44 rs187115 genotypic frequencies in 123 HCC patients without smoking.

VariableGenotypic frequencies
AA ( )AG+GG ( )OR (95% CI)AOR (95% CI)
(%) (%)

Clinical stage
 Stage I/II55 (74.3%)28 (57.1%)1.001.00
 Stage III/IV19 (25.7%)21 (42.9%)2.171 (1.006–4.687)*2.259 (1.036–4.924)*
Tumor size
 ≦T255 (74.3%)31 (63.3%)1.001.00
 >T219 (25.7%)18 (36.7%)1.681 (0.770–3.669)1.441 (0.409–5.077)
Lymph node metastasis
 No73 (98.6%)45 (91.8%)1.001.00
 Yes1 (1.4%)4 (8.2%)6.489 (0.703–59.899)6.876 (0.308–153.563)
Distant metastasis
 No72 (97.3%)44 (89.8%)1.001.00
 Yes2 (2.7%)5 (10.2%)4.091 (0.761–21.998)16.533 (0.848–322.266)
The Child-Pugh grade
 A54 (73.0%)36 (73.5%)1.001.00
 B or C20 (27.0%)13 (26.5%)0.975 (0.431–2.204)0.918 (0.244–3.455)
HBsAg
 Negative45 (60.8%)29 (59.2%)1.001.00
 Positive29 (39.2%)20 (40.8%)1.070 (0.512–2.235)1.229 (0.293–5.160)
Anti-HCV
 Negative42 (56.8%)25 (51.0%)1.001.00
 Positive32 (43.2%)24 (49.0%)1.260 (0.610–2.601)1.228 (0.342–4.410)
Liver cirrhosis
 Negative15 (20.3%)17 (34.7%)1.001.00
 Positive59 (79.7%)32 (65.3%)0.479 (0.211–1.083)0.295 (0.077–1.133)

The ORs analyzed by their 95% CIs were estimated by logistic regression models.
The AORs with their 95% CI were estimated by multiple logistic regression models, after controlling for age, gender, and alcohol consumption.
>T2: multiple tumor more than 5 cm or tumor involving a major branch of the portal or hepatic vein(s).
* value < 0.05 is statistically significant.