Implications of Heterogeneity in Multiple Myeloma

Table 3

Pathways commonly affected by mutations.

Pathway	Mutated genes
Cell cycle pathway including G1-S phase transition and checkpoints	CCNA1, CCNB1, CCND1, CDK4, CDK6, CDK7, CDKN1B, CDKN2A, CDKN2C, RBL1, CDK4, PRB1, ABL1, ATM, ATR, CDK6, SKP2, TGFB1, TGFB2, TGFB3
TERT pathway	MAX, MYC, SP1, SP3, WT1
p38 MAPK pathway	ATF2, DAXX, GRB2, HMGN1, MAP2K6, MAP3K7, MAP3K9, MAPK14, MAX, MEF2A, MEF2D, MKNK1, MYC, PLA2G4A, RAC1, RIPK1, RPS6KA5, SHC1, TGFB1, TGFB2, TGFB3, TRAF2
Histone methyltransferase	KDM6A, MLL, MLL2, MLL3, NSD1, WHSC1, WHSC1L1
NFKB pathway	BIRC2, BIRC3, BTRC, CARD10, CARD11, CARD6, CARD8, CYLD, FBXW11, IKBIP, IKBKAP, IKBKB, IKBKE, IL1R1, IRAK1, MAP3K14, MAP3K7, MYD88, NFKB2, NFKBIB, NOD2, RELA, RIPK1, RIPK2, RIPK4, TLR4, TRAF2, TRAF3, TRAF3IP1
Clotting pathway	COL4A1, COL4A2, COL4A3, COL4A5, COL4A6, F11, F3, F5, F7, F8, FGA, FGG, TFPI