Implications of Heterogeneity in Multiple Myeloma

Table 4

GEP-based prognostic signatures.

GEP signature	Methods
UAMS 70-gene [49]	Derived by comparing expression of profiles of patients with top and bottom quartile of survival treated on total therapy II
IFM signature [50]	Derived by comparing expression of profiles of patients with good and poor outcome in IFM trials
Centrosome index [51]	Based on expression of constituents of the centrosome
HZD cell death signature [52]	Signature derived from genes homozygously deleted in myeloma as detected by array comparative genomic hybridization
IL6-HMCL signature [53]	13-gene signature from genes induced upon IL6 stimulation of human myeloma cells lines
Proliferation index [54]	Curated signature based on proliferation genes
EMC 92-gene signature [55]	92-gene signature based on differentially expressed genes between patient with good and poor outcome on HOVON trial
Chromosome instability genomic event count (CINGEC) signature [56]	Based on differentially expressed genes between patients with the top and bottom quartile of genomic instability score based on number of genetic abnormalities identified by array comparative genomic hybridization