Table of Contents Author Guidelines Submit a Manuscript
BioMed Research International
Volume 2014, Article ID 236361, 9 pages
http://dx.doi.org/10.1155/2014/236361
Research Article

CpG Island Methylator Phenotype and Prognosis of Colorectal Cancer in Northeast China

1Department of Epidemiology, Public Health College, Harbin Medical University, Harbin, Heilongjiang 150081, China
2Department of Surgery, Cancer Hospital of Harbin Medical University, Harbin, Heilongjiang 150081, China

Received 18 February 2014; Accepted 23 July 2014; Published 28 August 2014

Academic Editor: Fumio Imazeki

Copyright © 2014 Xia Li et al. This is an open access article distributed under the Creative Commons Attribution License, which permits unrestricted use, distribution, and reproduction in any medium, provided the original work is properly cited.

Abstract

Purpose. To investigate the association between CpG island methylator phenotype (CIMP) and the overall survival of sporadic colorectal cancer (CRC) in Northeast China. Methods. 282 sporadic CRC patients were recruited in this study. We selected MLH1, MGMT, p16, APC, MINT1, MINT31, and RUNX3 as the CIMP panel markers. The promoter methylation was assessed by methylation sensitive high resolution melting (MS-HRM). Proportional hazards-regression models were fitted with computing hazard ratios (HR) and the corresponding 95% confidence intervals (95% CI). Results. 12.77% (36/282) of patients were CIMP-0, 74.1% (209/282) of patients were CIMP-L, and 13.12% (37/282) of patients were CIMP-H. The five-year survival of the 282 CRC patients was 58%. There was significant association between APC gene promoter methylation and CRC overall survival (HR = 1.61; 95% CI: 1.05–2.46; ). CIMP-H was significantly associated with worse prognosis compared to CIMP-0 (HR = 3.06; 95% CI: 1.19–7.89; ) and CIMP-L (HR = 1.97; 95% CI: 1.11–3.48; ), respectively. While comparing with the combine of CIMP-L and CIMP-0 (CIMP-L/0), CIMP-H also presented a worse prognosis (HR = 2.31; 95% CI: 1.02–5.24; ). Conclusion. CIMP-H may be a predictor of a poor prognosis of CRC in Northeast China patients.