CpG Island Methylator Phenotype and Prognosis of Colorectal Cancer in Northeast China

Table 4

Survival analysis on CRC patients according to CIMP status in tumor tissue in different tumor stages.

CIMP status	Stages I-II ()				Stages III-IV ()
	Univariate		Multivariate		Univariate		Multivariate
	HR and 95% CI		HR and 95% CI		HR and 95% CI		HR and 95% CI
CIMP-H versus CIMP-L/0	0.69 (0.17–2.91)	0.62	0.52 (0.12–2.22)	0.38	1.81 (1.02–3.24)	0.04	1.75 (0.95–3.23)	0.07
CIMP-H versus CIMP-L	0.74 (0.17–3.14)	0.68	0.57 (0.13–2.48)	0.46	1.73 (0.96–3.11)	0.07	1.50 (0.80–2.81)	0.20
CIMP-L versus CIMP-0	0.66 (0.27–1.60)	0.35	0.57 (0.23–1.41)	0.22	1.42 (0.60–3.34)	0.43	2.06 (0.77–5.53)	0.15
CIMP-H versus CIMP-0	0.71 (0.32–1.58)	0.40	0.56 (0.21–1.49)	0.24	1.55 (0.96–2.49)	0.07	1.67 (1.00–2.81)	0.05

Multivariate analysis, adjusted for age at diagnosis, tumor stage, tumor differentiation, and tumor location.