Table of Contents Author Guidelines Submit a Manuscript
BioMed Research International
Volume 2014, Article ID 238463, 7 pages
http://dx.doi.org/10.1155/2014/238463
Review Article

Mitochondrial Aging and Age-Related Dysfunction of Mitochondria

1Department of Medical Nanobiotechnology, Pirogov Russian State Medical University, Moscow 117997, Russia
2Laboratory of Medical Genetics, Russian Cardiology Research and Production Complex, Moscow 121552, Russia
3Laboratory of Cellular Mechanisms of Atherogenesis, Institute of General Pathology and Pathophysiology, Russian Academy of Medical Sciences, Moscow 125315, Russia
4Biological Faculty, N.P. Ogaryov Mordovian State University, Saransk 430005, Russia
5Institute for Atherosclerosis Research, Skolkovo Innovative Center, Moscow 143025, Russia
6Faculty of Medicine, University of New South Wales, Sydney, NSW 2052, Australia
7School of Medicine, University of Western Sydney, Campbelltown, NSW 2560, Australia

Received 16 December 2013; Accepted 19 March 2014; Published 10 April 2014

Academic Editor: Ancha Baranova

Copyright © 2014 Dimitry A. Chistiakov et al. This is an open access article distributed under the Creative Commons Attribution License, which permits unrestricted use, distribution, and reproduction in any medium, provided the original work is properly cited.

Linked References

  1. D. Harman, “The biologic clock: the mitochondria?” Journal of the American Geriatrics Society, vol. 20, no. 4, pp. 145–147, 1972. View at Google Scholar · View at Scopus
  2. D. Edgar and A. Trifunovic, “The mtDNA mutator mouse: dissecting mitochondrial involvement in aging,” Aging, vol. 1, no. 12, pp. 1028–1032, 2009. View at Google Scholar · View at Scopus
  3. R. Doonan, J. J. McElwee, F. Matthijssens et al., “Against the oxidative damage theory of aging: superoxide dismutases protect against oxidative stress but have little or no effect on life span in Caenorhabditis elegans,” Genes and Development, vol. 22, no. 23, pp. 3236–3241, 2008. View at Publisher · View at Google Scholar · View at Scopus
  4. W. X. Ding and X. M. Yin, “Mitophagy: mechanisms, pathophysiological roles, and analysis,” Biol Chem, vol. 393, pp. 547–564, 2012. View at Google Scholar
  5. K. R. Short, M. L. Bigelow, J. Kahl et al., “Decline in skeletal muscle mitochondrial function with aging in humans,” Proceedings of the National Academy of Sciences of the United States of America, vol. 102, no. 15, pp. 5618–5623, 2005. View at Publisher · View at Google Scholar · View at Scopus
  6. D. C. Wallace, “Mitochondrial DNA mutations in disease and aging,” Environmental and Molecular Mutagenesis, vol. 51, no. 5, pp. 440–450, 2010. View at Publisher · View at Google Scholar · View at Scopus
  7. M. F. Alexeyev, S. P. LeDoux, and G. L. Wilson, “Mitochondrial DNA and aging,” Clinical Science, vol. 107, no. 4, pp. 355–364, 2004. View at Publisher · View at Google Scholar · View at Scopus
  8. A. Trifunovic, A. Hansson, A. Wredenberg et al., “Somatic mtDNA mutations cause aging phenotypes without affecting reactive oxygen species production,” Proceedings of the National Academy of Sciences of the United States of America, vol. 102, no. 50, pp. 17993–17998, 2005. View at Publisher · View at Google Scholar · View at Scopus
  9. C. Richter, J.-W. Park, and B. N. Ames, “Normal oxidative damage to mitochondrial and nuclear DNA is extensive,” Proceedings of the National Academy of Sciences of the United States of America, vol. 85, no. 17, pp. 6465–6467, 1988. View at Google Scholar · View at Scopus
  10. R. Barazzoni, K. R. Short, and K. S. Nair, “Effects of aging on mitochondrial DNA copy number and cytochrome c oxidase gene expression in rat skeletal muscle, liver, and heart,” Journal of Biological Chemistry, vol. 275, no. 5, pp. 3343–3347, 2000. View at Publisher · View at Google Scholar · View at Scopus
  11. W. Yang and S. Hekimi, “A mitochondrial superoxide signal triggers increased longevity in caenorhabditis elegans,” PLoS Biology, vol. 8, no. 12, Article ID e1000556, 2010. View at Publisher · View at Google Scholar · View at Scopus
  12. S.-J. Lee, A. B. Hwang, and C. Kenyon, “Inhibition of respiration extends C. elegans life span via reactive oxygen species that increase HIF-1 activity,” Current Biology, vol. 20, no. 23, pp. 2131–2136, 2010. View at Publisher · View at Google Scholar · View at Scopus
  13. J. Sun, D. Folk, T. J. Bradley, and J. Tower, “Induced overexpression of mitochondrial Mn-superoxide dismutase extends the life span of adult Drosophila melanogaster,” Genetics, vol. 161, no. 2, pp. 661–672, 2002. View at Google Scholar · View at Scopus
  14. S. E. Schriner, N. J. Linford, G. M. Martin et al., “Medecine: extension of murine life span by overexpression of catalase targeted to mitochondria,” Science, vol. 308, no. 5730, pp. 1909–1911, 2005. View at Publisher · View at Google Scholar · View at Scopus
  15. R. M. Lebovitz, H. Zhang, H. Vogel et al., “Neurodegeneration, myocardial injury, and perinatal death in mitochondrial superoxide dismutase-deficient mice,” Proceedings of the National Academy of Sciences of the United States of America, vol. 93, no. 18, pp. 9782–9787, 1996. View at Publisher · View at Google Scholar · View at Scopus
  16. E. Migliaccio, M. Giorgio, and P. G. Pelicci, “Apoptosis and aging: role of p66Shc redox protein,” Antioxidants and Redox Signaling, vol. 8, no. 3-4, pp. 600–608, 2006. View at Publisher · View at Google Scholar · View at Scopus
  17. K. E. Conley, S. A. Jubrias, and P. C. Esselman, “Oxidative capacity and ageing in human muscle,” Journal of Physiology, vol. 526, no. 1, pp. 203–210, 2000. View at Google Scholar · View at Scopus
  18. E. J. Brierley, M. A. Johnson, A. Bowman et al., “Mitochondrial function in muscle from elderly athletes,” Annals of Neurology, vol. 41, no. 1, pp. 114–116, 1997. View at Publisher · View at Google Scholar · View at Scopus
  19. R. G. Larsen, D. M. Callahan, S. A. Foulis, and J. A. Kent-Braun, “Age-related changes in oxidative capacity differ between locomotory muscles and are associated with physical activity behavior,” Applied Physiology, Nutrition and Metabolism, vol. 37, no. 1, pp. 88–99, 2012. View at Publisher · View at Google Scholar · View at Scopus
  20. C. S. Palmer, L. D. Osellame, D. Stojanovski, and M. T. Ryan, “The regulation of mitochondrial morphology: intricate mechanisms and dynamic machinery,” Cellular Signalling, vol. 23, no. 10, pp. 1534–1545, 2011. View at Publisher · View at Google Scholar · View at Scopus
  21. J. D. Crane, M. C. Devries, A. Safdar, M. J. Hamadeh, and M. A. Tarnopolsky, “The effect of aging on human skeletal muscle mitochondrial and intramyocellular lipid ultrastructure,” The Journals of Gerontology Series A, vol. 65, no. 2, pp. 119–128, 2010. View at Publisher · View at Google Scholar · View at Scopus
  22. T. Wenz, S. G. Rossi, R. L. Rotundo, B. M. Spiegelman, and C. T. Moraes, “Increased muscle PGC-1α expression protects from sarcopenia and metabolic disease during aging,” Proceedings of the National Academy of Sciences of the United States of America, vol. 106, no. 48, pp. 20405–20410, 2009. View at Publisher · View at Google Scholar · View at Scopus
  23. T. Wenz, “Mitochondria and PGC-1α in aging and age-associated diseases,” Journal of Aging Research, vol. 2011, Article ID 810619, 12 pages, 2011. View at Publisher · View at Google Scholar
  24. G. Cavallini, A. Donati, M. Taddei, and E. Bergamini, “Evidence for selective mitochondrial autophagy and failure in aging,” Autophagy, vol. 3, no. 1, pp. 26–27, 2007. View at Google Scholar · View at Scopus
  25. E. Masiero and M. Sandri, “Autophagy inhibition induces atrophy and myopathy in adult skeletal muscles,” Autophagy, vol. 6, no. 2, pp. 307–309, 2010. View at Publisher · View at Google Scholar · View at Scopus
  26. S.-Y. Jeong and D.-W. Seol, “The role of mitochondria in apoptosis,” Journal of Biochemistry and Molecular Biology, vol. 41, no. 1, pp. 11–22, 2008. View at Google Scholar · View at Scopus
  27. E. Marzetti and C. Leeuwenburgh, “Skeletal muscle apoptosis, sarcopenia and frailty at old age,” Experimental Gerontology, vol. 41, no. 12, pp. 1234–1238, 2006. View at Publisher · View at Google Scholar · View at Scopus
  28. C. Leeuwenburgh, C. M. Gurley, B. A. Strotman, and E. E. Dupont-Versteegden, “Age-related differences in apoptosis with disuse atrophy in soleus muscle,” American Journal of Physiology, vol. 288, no. 5, pp. R1288–R1296, 2005. View at Publisher · View at Google Scholar · View at Scopus
  29. S. Y. Park, H. Y. Kim, J. H. Lee, K. H. Yoon, M. S. Chang, and S. K. Park, “The age-dependent induction of apoptosis-inducing factor (AIF) in the human semitendinosus skeletal muscle,” Cellular and Molecular Biology Letters, vol. 15, no. 1, pp. 1–12, 2010. View at Publisher · View at Google Scholar · View at Scopus
  30. S. A. Whitman, M. J. Wacker, S. R. Richmond, and M. P. Godard, “Contributions of the ubiquitin-proteasome pathway and apoptosis to human skeletal muscle wasting with age,” Pflugers Archiv European Journal of Physiology, vol. 450, no. 6, pp. 437–446, 2005. View at Publisher · View at Google Scholar · View at Scopus
  31. E. Bolton and C. Rajkumar, “The ageing cardiovascular system,” Reviews in Clinical Gerontology, vol. 21, no. 2, pp. 99–109, 2011. View at Publisher · View at Google Scholar · View at Scopus
  32. J. C. Wang and M. Bennett, “Aging and atherosclerosis: mechanisms, functional consequences, and potential therapeutics for cellular senescence,” Circulation Research, vol. 111, pp. 245–259, 2012. View at Google Scholar
  33. D. A. Chistiakov, I. A. Sobenin, Y. V. Bobryshev, and A. N. Orekhov, “Mitochondrial dysfunction and mitochondrial DNA mutations in atherosclerotic complications in diabetes,” World Journal of Cardiology, vol. 4, pp. 148–156, 2012. View at Google Scholar
  34. I. A. Sobenin, D. A. Chistiakov, Y. V. Bobryshev, A. Y. Postnov, and A. N. Orekhov, “Mitochondrial mutations in atherosclerosis: new solutions in research and possible clinical applications,” Current Pharmaceutical Design, vol. 19, pp. 5942–5953, 2013. View at Google Scholar
  35. W. J. Craigen, “Mitochondrial DNA mutations: an overview of clinical and molecular aspects,” Methods in Molecular Biology, vol. 837, pp. 3–15, 2012. View at Publisher · View at Google Scholar · View at Scopus
  36. T. J. Nicholls, J. Rorbach, and M. Minczuk, “Mitochondria: mitochondrial RNA metabolism and human disease,” The International Journal of Biochemistry & Cell Biology, vol. 45, pp. 845–849, 2013. View at Google Scholar
  37. I. A. Sobenin, M. A. Sazonova, A. Y. Postnov, J. T. Salonen, Y. V. Bobryshev, and A. N. Orekhov, “Association of mitochondrial genetic variation with carotid atherosclerosis,” PLoS ONE, vol. 8, Article ID e68070, 2013. View at Google Scholar
  38. I. A. Sobenin, M. A. Sazonova, A. Y. Postnov, Y. V. Bobryshev, and A. N. Orekhov, “Changes of mitochondria in atherosclerosis: possible determinant in the pathogenesis of the disease,” Atherosclerosis, vol. 227, pp. 283–288, 2013. View at Google Scholar
  39. H. D. Osiewacz and D. Bernhardt, “Mitochondrial quality control: impact on aging and life span—a mini-review,” Gerontology, vol. 59, pp. 413–420, 2013. View at Google Scholar
  40. C. Adam, M. Picard, M. Dequard-Chablat, C. H. Sellem, S. H. Denmat, and V. Contamine, “Biological roles of the Podospora anserina mitochondrial Lon protease and the importance of its N-domain,” PLoS ONE, vol. 7, Article ID e38138, 2012. View at Google Scholar
  41. J. K. Ngo, L. C. D. Pomatto, and K. J. A. Davies :, “Upregulation of the mitochondrial Lon Protease allows adaptation to acute oxidative stress but dysregulation is associated with chronic stress, disease, and aging,” Redox Biology, vol. 1, pp. 258–264, 2013. View at Google Scholar
  42. E. B. Taylor and J. Rutter, “Mitochondrial quality control by the ubiquitin-proteasome system,” Biochemical Society Transactions, vol. 39, no. 5, pp. 1509–1513, 2011. View at Publisher · View at Google Scholar · View at Scopus
  43. P. Löw, “The role of ubiquitin-proteasome system in ageing,” General and Comparative Endocrinology, vol. 172, no. 1, pp. 39–43, 2011. View at Publisher · View at Google Scholar · View at Scopus
  44. M. Altun, H. C. Besche, H. S. Overkleeft et al., “Muscle wasting in aged, sarcopenic rats is associated with enhanced activity of the ubiquitin proteasome pathway,” Journal of Biological Chemistry, vol. 285, no. 51, pp. 39597–39608, 2010. View at Publisher · View at Google Scholar · View at Scopus
  45. Y. Pan, Y. Nishida, M. Wang, and E. Verdin, “Metabolic regulation, mitochondria and the life-prolonging effect of rapamycin: a mini-review,” Gerontology, vol. 58, pp. 524–530, 2012. View at Google Scholar
  46. C. M. Peterson, D. L. Johannsen, and E. Ravussin, “Skeletal muscle mitochondria and aging: a review,” Journal of Aging Research, vol. 2012, Article ID 194821, 20 pages, 2012. View at Publisher · View at Google Scholar
  47. A. E. Civitarese, S. Carling, L. K. Heilbronn et al., “Calorie restriction increases muscle mitochondrial biogenesis in healthy humans,” PLoS Medicine, vol. 4, no. 3, pp. 485–494, 2007. View at Publisher · View at Google Scholar · View at Scopus
  48. J. L. Steiner, E. A. Murphy, J. L. McClellan, M. D. Carmichael, and J. M. Davis, “Exercise training increases mitochondrial biogenesis in the brain,” Journal of Applied Physiology, vol. 111, no. 4, pp. 1066–1071, 2011. View at Publisher · View at Google Scholar · View at Scopus
  49. K. R. Short, J. L. Vittone, M. L. Bigelow et al., “Impact of aerobic exercise training on age-related changes in insulin sensitivity and muscle oxidative capacity,” Diabetes, vol. 52, no. 8, pp. 1888–1896, 2003. View at Publisher · View at Google Scholar · View at Scopus
  50. S. Ghosh, R. Lertwattanarak, N. Lefort et al., “Reduction in reactive oxygen species production by mitochondria from elderly subjects with normal and impaired glucose tolerance,” Diabetes, vol. 60, no. 8, pp. 2051–2060, 2011. View at Publisher · View at Google Scholar · View at Scopus
  51. N. Psilander, P. Frank, M. Flockhart, and K. Sahlin, “Exercise with low glycogen increases PGC-1α gene expression in human skeletal muscle,” European Journal of Applied Physiology, vol. 113, pp. 951–963, 2013. View at Google Scholar
  52. M. Lefevre, L. M. Redman, L. K. Heilbronn et al., “Caloric restriction alone and with exercise improves CVD risk in healthy non-obese individuals,” Atherosclerosis, vol. 203, no. 1, pp. 206–213, 2009. View at Publisher · View at Google Scholar · View at Scopus