Heat Shock Proteins at the Crossroads between Cancer and Alzheimer’s Disease

Figure 2

The role of Hsp70 and Hsp90 chaperone in the regulation of tau protein. The dephosphorylation and refolding of protein tau is facilitated by Hsp70/90 complex, preventing degradation; when the Hsp90 inhibition is initiated, tau is transferred to the Hsp70/CHIP complex undergoing degradation. The inhibition of Hsp90 promotes the depolymerization of Hsp90-containing HSF1 complex and induces HSF1 into homotrimer to activate HSP gene expression.