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BioMed Research International
Volume 2014 (2014), Article ID 239462, 11 pages
http://dx.doi.org/10.1155/2014/239462
Research Article

Identification of Influenza A/H7N9 Virus Infection-Related Human Genes Based on Shortest Paths in a Virus-Human Protein Interaction Network

1Department of Biomedical Engineering, Tianjin University, Tianjin Key Lab of BME Measurement, Tianjin 300072, China
2State Key Laboratory of Medical Genomics, Institute of Health Sciences, Shanghai Jiaotong University School of Medicine and Shanghai Institutes for Biological Sciences, Chinese Academy of Sciences, Shanghai 200025, China
3Department of Genetics and Genomic Sciences, Mount Sinai School of Medicine, New York City, NY, USA
4Institute of Systems Biology, Shanghai University, 99 Shangda Road, Shanghai 200444, China

Received 10 March 2014; Revised 18 April 2014; Accepted 21 April 2014; Published 18 May 2014

Academic Editor: Lei Chen

Copyright © 2014 Ning Zhang et al. This is an open access article distributed under the Creative Commons Attribution License, which permits unrestricted use, distribution, and reproduction in any medium, provided the original work is properly cited.

Supplementary Material

Supporting Information S1: Sequences of the 11 non-homologous influenza A/H7N9 virus proteins downloaded from NCBI protein database, with pairwise sequence identity less than 40%.

Supporting Information S2: The interacting influenza A/H7N9 virus-human protein pairs with their sharing GO terms. The interacting HRV-human and RSV-human protein pairs were also included respectively.

Supporting Information S3: The 3,212 Target Human Proteins interacted with influenza A/H7N9 virus proteins, found based on sharing GO terms. The Target Human Proteins interacted with HRV and RSV viruses were also included respectively.

Supporting Information S4: The 962 shortest path human proteins picked out on shortest paths for influenza A/H7N9 virus. The shortest path human proteins for HRV and RSV viruses were also included respectively.

Supporting Information S5: Sequences of the 4 non-homologous Human Rhinovirus (HRV) proteins downloaded from NCBI protein database, with pairwise sequence identity less than 40%.

Supporting Information S6: Sequences of the 22 non-homologous Respiratory Syncytical Virus (RSV) proteins downloaded from NCBI protein database, with pairwise sequence identity less than 40%.

  1. Supplementary Materials