Protective Effect of Ethanolic Extract of Tabernaemontana divaricata (L.) R. Br. against DEN and Fe NTA Induced Liver Necrosis in Wistar Albino Rats

Table 3

Changes in the level of lipid peroxidation and enzymatic antioxidants in liver.

Particulars	Control (Group I)	DEN + Fe-NTA (Group II)	DEN & Fe-NTA + plant extract (200 mg/kg) (Group III)	DEN & Fe-NTA + plant extract (400 mg/kg) (Group IV)	Plant extract alone (200 mg/kg) (Group V)	Plant extract alone (400 mg/kg) (Group VI)	DEN & Fe-NTA + Std drug (GroupVII)
Lipid peroxidation in liver	1.56 ± 0.06^a	4.95 ± 0.14^b	2.56 ± 0.08^c	1.74 ± 0.09^d	1.58 ± 0.06^a	1.54 ± 0.06^a	1.59 ± 0.06^a
SOD	11.08 ± 0.46^a	6.19 ± 0.30^b	9.96 ± 0.23^c	10.92 ± 0.54^a	11.39 ± 0.22^a	12.62 ± 0.28^a	10.41 ± 0.42^a
Catalase	6.01 ± 0.05^a	3.25 ± 0.26^b	4.33 ± 0.08^c	6.04 ± 0.09^a	5.96 ± 0.07^a	6.19 ± 0.07^a	6.03 ± 0.03^a
PX	40.22 ± 0.59^a	16.85 ± 0.91^b	35.64 ± 0.16^c	39.33 ± 0.65^d	39.30 ± 0.38^d	38.94 ± 0.4^d	39.19 ± 0.34^d
GST	131.22 ± 2.7^a	98.08 ± 2.84^b	112.86 ± 2.62^c	130.07 ± 0.60^a	130.66 ± 1.27^a	132.56 ± 0.65^a	131.08 ± 1.99^a
G6PD	13.95 ± 0.11^a	5.46 ± 0.24^b	8.67 ± 0.09^c	13.51 ± 0.4^a	13.8 ± 0.21^a	13.88 ± 0.12^a	13.7 ± 0.18^a
GPx	43.94 ± 0.34^a	21.58 ± 0.59^b	30.64 ± 0.24^c	45.06 ± 0.59^d	45.54 ± 0.44^d	46.59 ± 0.39^e	46.16 ± 0.7^e

Values are expressed as mean ± SD (𝑛=6).
Values not sharing the common superscript differ significantly (DMRT).
Units are as follows: SOD—unit/mg protein; CAT—µ moles of H₂O₂ consumed/min/mg protein;
Px—units/g tissue:
LPO—nmoles of MDA formed/mg protein.