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BioMed Research International
Volume 2014, Article ID 240284, 16 pages
Research Article

Phenomics Research on Coronary Heart Disease Based on Human Phenotype Ontology

1The Key Institute of State Administration of Traditional Chinese Medicine (Pneumonopathy Chronic Cough and Dyspnea), China-Japan Friendship Hospital, Beijing 100029, China
2Beijing University of Chinese Medicine, Bei San Huan East Road, Beijing 100029, China
3Institute of Automation, Chinese Academy of Sciences, Zhongguancun East Road, Beijing 100190, China

Received 8 May 2014; Revised 28 August 2014; Accepted 12 September 2014; Published 15 December 2014

Academic Editor: Tatsuya Akutsu

Copyright © 2014 Qi Shi et al. This is an open access article distributed under the Creative Commons Attribution License, which permits unrestricted use, distribution, and reproduction in any medium, provided the original work is properly cited.


The characteristics of holistic, dynamics, complexity, and spatial and temporal features enable “Omics” and theories of TCM to interlink with each other. HPO, namely, “characterization,” can be understood as a sorting and generalization of the manifestations shown by people with diseases on the basis of the phenomics. Syndrome is the overall “manifestation” of human body pathological and physiological changes expressed by four diagnostic methods’ information. The four diagnostic methods’ data could be the most objective and direct manifestations of human body under morbid conditions. In this aspect, it is consistent with the connation of “characterization.” Meanwhile, the four diagnostic methods’ data also equip us with features of characterization in HPO. In our study, we compared 107 pieces of four diagnostic methods’ information with the “characterization database” to further analyze data of four diagnostic methods’ characterization in accordance with the common characteristics of four diagnostic methods’ information and characterization and integrated 107 pieces of four diagnostic methods’ data to relevant items in HPO and finished the expansion of characterization information in HPO.