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BioMed Research International
Volume 2014, Article ID 240873, 6 pages
http://dx.doi.org/10.1155/2014/240873
Research Article

Relationship between GH/IGF-1 Axis, Graft Recovery, and Early Survival in Patients Undergoing Liver Transplantation

1Hepatology Unit, Department of Internal Medicine, University of Rome “Tor Vergata”, Via Montpellier 1, 00133 Rome, Italy
2Transplant Unit, Department of Surgery, “Tor Vergata” University, Via Montpellier 1, 00133 Rome, Italy

Received 10 February 2014; Revised 27 February 2014; Accepted 5 March 2014; Published 1 April 2014

Academic Editor: Salvador Benlloch

Copyright © 2014 Angela Salso et al. This is an open access article distributed under the Creative Commons Attribution License, which permits unrestricted use, distribution, and reproduction in any medium, provided the original work is properly cited.

Linked References

  1. R. G. Rosenfeld and V. Hwa, “The growth hormone cascade and its role in mammalian growth,” Hormone Research, vol. 71, supplement 2, pp. 36–40, 2009. View at Publisher · View at Google Scholar · View at Scopus
  2. A. M. Lichanska and M. J. Waters, “How growth hormone controls growth, obesity and sexual dimorphism,” Trends in Genetics, vol. 24, no. 1, pp. 41–47, 2008. View at Publisher · View at Google Scholar · View at Scopus
  3. D. E. Berryman, J. S. Christiansen, G. Johannsson, M. O. Thorner, and J. J. Kopchick, “Role of the GH/IGF-1 axis in lifespan and healthspan: lessons from animal models,” Growth Hormone and IGF Research, vol. 18, no. 6, pp. 455–471, 2008. View at Publisher · View at Google Scholar · View at Scopus
  4. M. Rincon, E. Rudin, and N. Barzilai, “The insulin/IGF-1 signaling in mammals and its relevance to human longevity,” Experimental Gerontology, vol. 40, no. 11, pp. 873–877, 2005. View at Publisher · View at Google Scholar · View at Scopus
  5. G. Mariño, A. P. Ugalde, A. F. Fernández et al., “Insulin-like growth factor 1 treatment extends longevity in a mouse model of human premature aging by restoring somatotroph axis function,” Proceedings of the National Academy of Sciences of the USA, vol. 107, pp. 16268–16273, 2010. View at Google Scholar
  6. E. Shmueli, M. Stewart, K. G. M. M. Alberti, and C. O. Record, “Growth hormone, insulin-like growth factor-1 and insulin resistance in cirrhosis,” Hepatology, vol. 19, no. 2, pp. 322–328, 1994. View at Publisher · View at Google Scholar · View at Scopus
  7. Y. Baruch, N. Assy, T. Amit et al., “Spontaneous pulsatility and pharmacokinetics of growth hormone in liver cirrhotic patients,” Journal of Hepatology, vol. 29, no. 4, pp. 559–564, 1998. View at Publisher · View at Google Scholar · View at Scopus
  8. M. C. Blomsma, R. J. de Knegt, R. P. F. Dullaart, and P. L. M. Jansen, “Insulin-like growth factor-I in liver cirrhosis,” Journal of Hepatology, vol. 27, no. 6, pp. 1133–1138, 1997. View at Publisher · View at Google Scholar · View at Scopus
  9. K. Bonefeld and S. Møller, “Insulin-like growth factor-I and the liver,” Liver International, vol. 3, pp. 911–919, 2011. View at Google Scholar
  10. L. Caregaro, F. Alberino, P. Amodio et al., “Nutritional and prognostic significance of insulin-like growth factor 1 in patients with liver cirrhosis,” Nutrition, vol. 13, no. 3, pp. 185–190, 1997. View at Google Scholar · View at Scopus
  11. L. Caregaro, F. Alberino, P. Angeli, and A. Gatta, “Insulin-like growth factor 1 (IGF-1) in liver cirrhosis: a marker of hepatocellular dysfunction?” Journal of Hepatology, vol. 29, no. 2, article 342, 1998. View at Publisher · View at Google Scholar · View at Scopus
  12. N. Li, L. Zhou, B. Zhang et al., “Recombinant human growth hormone increases albumin and prolongs survival in patients with chronic liver failure: a pilot open, randomized, and controlled clinical trial,” Digestive and Liver Disease, vol. 40, no. 7, pp. 554–559, 2008. View at Publisher · View at Google Scholar · View at Scopus
  13. M. Conchillo, R. J. De Knegt, M. Payeras et al., “Insulin-like growth factor I (IGF-I) replacement therapy increases albumin concentration in liver cirrhosis: results of a pilot randomized controlled clinical trial,” Journal of Hepatology, vol. 43, no. 4, pp. 630–636, 2005. View at Publisher · View at Google Scholar · View at Scopus
  14. D. S. Schalch, M. Kalayoglu, J. D. Pirsch, H. Yang, M. Raslich, and S. Rajpal, “Serum insulin-like growth factors and their binding proteins in patients with hepatic failure and after liver transplantation,” Metabolism: Clinical and Experimental, vol. 47, no. 2, pp. 200–206, 1998. View at Publisher · View at Google Scholar · View at Scopus
  15. M. M. Weber, C. J. Auernhammer, P. D. K. Lee, D. Engelhardt, and R. Zachoval, “Insulin-like growth factors and insulin-like growth factor binding proteins in adult patients with severe liver disease before and after orthotopic liver transplantation,” Hormone Research, vol. 57, no. 3-4, pp. 105–112, 2002. View at Publisher · View at Google Scholar · View at Scopus
  16. D. Seehofer, T. Steinmueller, K.-J. Graef et al., “Pituitary function test and endocrine status in patient with cirrhosis of the liver before and after hepatic transplantation,” Annals of Transplantation, vol. 7, no. 2, pp. 32–37, 2002. View at Google Scholar · View at Scopus
  17. G. R. Castro, J. C. Coelho, M. B. Parolin, J. E. Matias, and A. C. de Freitas, “Insulin-like growth factor I correlates with MELD and returns to normal level after liver transplantation,” Annals of Transplantation, vol. 18, pp. 57–62, 2013. View at Google Scholar
  18. M. Bassanello, E. F. de Palo, F. Lancerin et al., “Growth hormone/insulin-like factor 1 axis recovery after liver transplantation: a preliminary prospective study,” Liver Transplantation, vol. 10, no. 5, pp. 692–698, 2004. View at Publisher · View at Google Scholar · View at Scopus
  19. L. Urbani, A. Campatelli, J. Romagnoli et al., “T-tube removal after liver transplantation: a new technique that reduces biliary complications,” Transplantation, vol. 74, no. 3, pp. 410–413, 2002. View at Google Scholar · View at Scopus
  20. L. Falasca, G. Tisone, G. Palmieri et al., “Protective role of tauroursodeoxycholate during harvesting and cold storage of human liver,” Transplantation, vol. 71, no. 9, pp. 1268–1276, 2001. View at Google Scholar · View at Scopus
  21. L. Baiocchi, M. Angelico, A. Petrolati et al., “Correlation between liver fibrosis and inflammation in patients transplanted for HCV liver disease,” American Journal of Transplantation, vol. 8, no. 3, pp. 673–678, 2008. View at Publisher · View at Google Scholar · View at Scopus
  22. L. Baiocchi, F. De Leonardis, M. Delle Monache et al., “Plasma/erythrocyte ribavirin x100 ratio as an indicator of sustained virological response in HCV genotype 1 patients with early virological response,” Antiviral Therapy, vol. 15, no. 4, pp. 633–639, 2010. View at Publisher · View at Google Scholar · View at Scopus
  23. P. Cesaro, A. Kohn, L. Petruziello et al., “A survey on mortality from non-variceal upper gastrointestinal bleeding: is the emergency referral system adequate?” Digestive and Liver Disease, vol. 45, pp. 953–956, 2013. View at Google Scholar
  24. P. Dutkowski, O. De Rougemont, B. Müllhaupt, and P.-A. Clavien, “Current and future trends in liver transplantation in Europe,” Gastroenterology, vol. 138, no. 3, pp. 802–809, 2010. View at Publisher · View at Google Scholar · View at Scopus
  25. C. L. Berg, D. E. Steffick, E. B. Edwards et al., “Liver and intestine transplantation in the United States 1998–2007,” The American Journal of Transplantation, vol. 9, no. 4, pp. 907–931, 2009. View at Publisher · View at Google Scholar · View at Scopus
  26. P. H. Hayashi, L. Forman, T. Steinberg et al., “Model for end-stage liver diseases score does not predict patient or graft survival in living donor liver transplant recipients,” Liver Transplantation, vol. 9, no. 7, pp. 737–740, 2003. View at Publisher · View at Google Scholar · View at Scopus
  27. N. M. Desai, K. C. Mange, M. D. Crawford et al., “Predicting outcome after liver transplantation: utility of the model for end-stage liver disease and a newly derived discrimination function,” Transplantation, vol. 77, no. 1, pp. 99–106, 2004. View at Publisher · View at Google Scholar · View at Scopus
  28. C.-S. Wong, W.-C. Lee, C.-C. Jenq et al., “Scoring short-term mortality after liver transplantation,” Liver Transplantation, vol. 16, no. 2, pp. 138–146, 2010. View at Publisher · View at Google Scholar · View at Scopus
  29. E. F. De Palo, M. Bassanello, F. Lancerin et al., “GH/IGF system, cirrhosis and liver transplantation,” Clinica Chimica Acta, vol. 310, no. 1, pp. 31–37, 2001. View at Publisher · View at Google Scholar · View at Scopus
  30. R. Pfitzmann, B. Benscheidt, J. M. Langrehr, G. Schumacher, R. Neuhaus, and P. Neuhaus, “Trends and experiences in liver retransplantation over 15 years,” Liver Transplantation, vol. 13, no. 2, pp. 248–257, 2007. View at Publisher · View at Google Scholar · View at Scopus
  31. R. M. Ghobrial, “Changing faces of liver retransplantation: it is all about selection,” Liver Transplantation, vol. 13, no. 2, pp. 188–189, 2007. View at Publisher · View at Google Scholar · View at Scopus