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BioMed Research International
Volume 2014 (2014), Article ID 245171, 9 pages
http://dx.doi.org/10.1155/2014/245171
Research Article

Hepatoprotective and Antioxidant Effect of Bauhinia hookeri Extract against Carbon Tetrachloride-Induced Hepatotoxicity in Mice and Characterization of Its Bioactive Compounds by HPLC-PDA-ESI-MS/MS

1Department of Pharmacognosy, Faculty of Pharmacy, Ain-Shams University, Cairo 11566, Egypt
2Laboratory of Organic Chemistry and Chemical Biology, Department of Chemistry, University of Turku, 20014 Turku, Finland
3Department of Pharmacology, Theodor Bilharz Research Institute, Giza 12411, Egypt
4Department of Pathology, School of Medicine, Stanford University, Stanford, CA 94305, USA
5Department of Pharmacology, Faculty of Veterinary Medicine, Suez Canal University, Ismailia 41522, Egypt
6Center for Emerging Infectious Diseases, Gifu University, 1-1 Yanagido, Gifu 501-1194, Japan

Received 27 February 2014; Revised 26 April 2014; Accepted 26 April 2014; Published 14 May 2014

Academic Editor: Sung-Hoon Kim

Copyright © 2014 Eman Al-Sayed et al. This is an open access article distributed under the Creative Commons Attribution License, which permits unrestricted use, distribution, and reproduction in any medium, provided the original work is properly cited.

Supplementary Material

Bauhinia hookeri ethanol extract (BHE) confered marked amelioration of the pathological changes induced by CCl4 at the two treatment doses (500 and 1000 mg/kg) as evidenced by the preserved hepatic architecture, the marked decrease in lymphocyte infiltration, hydropic degeneration, fatty changes, central vein congestion, Kupffer cell hyperplasia and necrotic changes. It was clear that the lower dose of BHE is as effective as silymarin in reducing the Kupffer cell hyperplasia induced by CCl4 intoxication. BHE treatment inhibited the fatty changes, central vein congestion and necrosis more than in the silymarin-treated group. Complete amelioration of the fatty changes was evident by the higher dose of BHE.

  1. Supplementary Material