|
| Growth factor | Function |
|
| EGF | Cellular proliferation |
| Differentiation of epithelial cells |
|
| FGF | Stimulates angiogenesis |
| Cellular migration |
| Stimulates the proliferation of capillary endothelial cells |
| Production of granulation tissue |
|
| HGF | Stimulation of hepatocyte proliferation and liver tissue regeneration |
| Stimulates angiogenesis |
| Mitogen for endothelial cells |
| Antifibrotic |
|
| IGF-1 | Proliferation of myoblasts and fibroblasts |
| Stimulation of protein synthesis |
| Mediator in growth and repair of skeletal muscle |
| Enhances bone formation by proliferation and differentiation of osteoblasts |
| Enhances collagen and matrix synthesis |
|
| PDAF | Induces vascularization by stimulating vascular endothelial cells |
|
| PDEGF | Stimulates the proliferation of keratinocytes and dermal fibroblasts |
|
| PDGF | Macrophage activation |
| Stimulates angiogenesis |
| Fibroblast chemotaxis and proliferative activity |
| Attracts stem cells and white blood cells |
| Enhances collagen synthesis |
| Contributes to tissue remodeling |
| Enhances the proliferation of bone cells |
|
| TGF- | Enhances the proliferative activity of fibroblasts |
| Stimulates biosynthesis of type 1 collagen and fibronectin |
| Induces deposition of bone matrix |
| Inhibits osteoclast formation and bone resorption |
| Regulation in balance between fibrosis and myocyte regeneration |
| Control of angiogenesis and fibrosis |
| Immunosuppressant during inflammatory phase |
|
| VEGF | Stimulates angiogenesis |
| Migration and mitosis of endothelial cells |
| Creation of blood vessel lumen |
| Chemotactic for macrophages and granulocytes |
| Vasodilation |
|
