Synthesis and Evaluation of Novel Pyrroles and Pyrrolopyrimidines as Anti-Hyperglycemic Agents

Table 1

Effect of various treatments on the mean area under curve (AUC) of blood glucose levels in rats.

Tested; compound(s)	% reduction in blood glucose compared to control
	SLM	STZ
Amaryl; [Standard drug]	27.7 ^a	30.4 ^a
[ Ia ]	17.4 ^a	33.3 ^a
[ Ib ]	10.9 ^a	NA
[ Ic ]	18 ^a	35.3 ^a
[ Id ]	NA	NA
[ Ie ]	16.7 ^a	29.5 ^a
[ IVg ]	13 ^a	11.2 ^a
[ VIf ]	NA	NA
[ VIIa ]	NA	NA
[ VIIb ]	NA	NA
[ VIIf ]	NA	NA
[ VIIIa ]	NA	NA
[ VIIIf ]	NA	NA

NA = not active.
aConsidered significant compared to control (𝑃≤0.05).
SLM: Sucrose-Loaded Model; STZ: Streptozotocin model of diabetes.