A Knowledge-Driven Approach to Extract Disease-Related Biomarkers from the Literature

Table 4

The top 10 genes sorted by the number of associated diseases. The complete list of genes is available at http://ibi.imim.es/biomarkers/.

Gene symbol	Gene ID^a	Gene name	Number of diseases
IL6	3569	Interleukin 6 (interferon, beta 2)	1,025
TNF	7124	Tumor necrosis factor	1,003
CD4	920	CD4 molecule	917
ICAM1	3383	Intercellular adhesion molecule 1	841
TP53	7157	Tumor protein p53	797
CRP	1401	C-reactive protein, pentraxin-related	786
CD8A	925	CD8a molecule	771
CD34	947	CD34 molecule	742
VEGFA	7422	Vascular endothelial growth factor A	704
ACE	1636	Angiotensin I converting enzyme	666

aNCBI gene identifier.