Usefulness of Anticoagulant Therapy in the Prevention of Embolic Complications in Patients with Acute Infective Endocarditis

Table 4

Factors associated with embolism in patients with IE.

	Univariate analysis	P	Multivariate analysis	P
	OR (95% CI)		OR (95% CI)
Age ≥ 65 years	0.560 (0.230–1.365)	0.202	0.657 (0.260–1.665)	0.376
Male gender	1.409 (0.688–2.887)	0.348
Hypertension	1.024 (0.429–2.443)	0.957
Diabetes mellitus	0.730 (0.305–1.747)	0.480
Atrial fibrillation	0.719 (0.341–1.515)	0.385
History of CHF	0.620 (0.291–1.322)	0.216
Comorbidity index > 2	0.973 (0.435–2.180)	0.948
Prosthetic valves	0.472 (0.236–0.941)	0.033
Mitral valve IE	1.623 (0.730–3.607)	0.235	1.397 (0.612–3.187)	0.427
Aortic valve IE	0.765 (0.394–1.483)	0.427
Vegetation > 1 cm	3.066 (1.542–6.093)	0.001
Mobile vegetation	5.584 (2.671–11.677)	<0.001
Staphylococcus aureus	2.833 (1.080–7.436)	0.034	2.947 (1.090–7.965)	0.033
Warfarin at admission	0.493 (0.237–1.025)	0.058	0.488 (0.228–1.047)	0.065

CHF: congestive heart failure; IE: infective endocarditis.