Table of Contents Author Guidelines Submit a Manuscript
BioMed Research International
Volume 2014 (2014), Article ID 256723, 8 pages
http://dx.doi.org/10.1155/2014/256723
Research Article

Coexpression of SFRP1 and WIF1 as a Prognostic Predictor of Favorable Outcomes in Patients with Colorectal Carcinoma

1Department of Anorectal Surgery and Colorectal Cancer Center, Xinhua Hospital, School of Medicine, Shanghai Jiao Tong University, No. 1665 Kongjiang Road, Shanghai 200092, China
2Department of Tumor Radiotherapy and Chemotherapy, Jiangxi Tumor Hospital, Nanchang, China
3Department of Gastroenterology, Changhai Hospital, Second Military Medical University, Shanghai, China
4Department of Gastrointestinal Surgery, Sichuan Academy of Medical Sciences and Sichuan Provincial People’s Hospital, Chengdu, Sichuan, China
5Department of Oncology, Ya’an People’s Hospital, No. 358 Chenghou Road, Ya’an, Sichuan 610072, China

Received 10 February 2014; Revised 16 April 2014; Accepted 23 April 2014; Published 14 May 2014

Academic Editor: Robert Stoehr

Copyright © 2014 Shiyong Huang et al. This is an open access article distributed under the Creative Commons Attribution License, which permits unrestricted use, distribution, and reproduction in any medium, provided the original work is properly cited.

Linked References

  1. K. Y. Wolin, A. V. Patel, P. T. Campbell et al., “Change in physical activity and colon cancer incidence and mortality,” Cancer Epidemiology Biomarkers and Prevention, vol. 19, no. 12, pp. 3000–3004, 2010. View at Publisher · View at Google Scholar · View at Scopus
  2. Z. C. Wang, J. Gao, S. M. Zi, M. Yang, P. Du, and L. Cui, “Aberrant expression of sonic hedgehog pathway in colon cancer and melanosis coli,” Journal of Digestive Diseases, vol. 14, pp. 417–424, 2013. View at Google Scholar
  3. Z. Yang, Y. Wang, J. Fang et al., “Expression and aberrant promoter methylation of Wnt inhibitory factor-1 in human astrocytomas,” Journal of Experimental & Clinical Cancer Research, vol. 29, p. 26, 2010. View at Publisher · View at Google Scholar · View at Scopus
  4. H. Clevers and R. Nusse, “Wnt/beta-catenin signaling and disease,” Cell, vol. 149, pp. 1192–1205, 2012. View at Google Scholar
  5. N. Amin and E. Vincan, “The Wnt signaling pathways and cell adhesion,” Frontiers in Bioscience, vol. 17, no. 2, pp. 784–804, 2012. View at Publisher · View at Google Scholar · View at Scopus
  6. W. Gu, X. Li, and J. Wang, “miR-139 regulates the proliferation and invasion of hepatocellular carcinoma through the WNT/TCF-4 pathway,” Oncology Reports, vol. 31, pp. 397–404, 2014. View at Google Scholar
  7. N. Yamada, S. Noguchi, T. Mori, T. Naoe, K. Maruo, and Y. Akao, “Tumor-suppressive microRNA-145 targets catenin delta-1 to regulate Wnt/beta-catenin signaling in human colon cancer cells,” Cancer Letters, vol. 335, pp. 332–342, 2013. View at Google Scholar
  8. P. J. Morin, A. B. Sparks, V. Korinek et al., “Activation of β-catenin-Tcf signaling in colon cancer by mutations in β-catenin or APC,” Science, vol. 275, no. 5307, pp. 1787–1790, 1997. View at Publisher · View at Google Scholar · View at Scopus
  9. Q. Feng Han, W. Zhao, J. Bentel et al., “Expression of sFRP-4 and β-catenin in human colorectal carcinoma,” Cancer Letters, vol. 231, no. 1, pp. 129–137, 2006. View at Publisher · View at Google Scholar · View at Scopus
  10. J. Zhu, Y. Wang, J. Duan et al., “DNA Methylation status of Wnt antagonist SFRP5 can predict the response to the EGFR-tyrosine kinase inhibitor therapy in non-small cell lung cancer,” Journal of Experimental & Clinical Cancer Research, vol. 31, p. 80, 2012. View at Google Scholar
  11. K. Kawakami, S. Yamamura, H. Hirata et al., “Secreted frizzled-related protein-5 is epigenetically downregulated and functions as a tumor suppressor in kidney cancer,” International Journal of Cancer, vol. 128, no. 3, pp. 541–550, 2011. View at Publisher · View at Google Scholar · View at Scopus
  12. Y. W. Zhang, Y. F. Miao, J. Yi, J. Geng, R. Wang, and L. B. Chen, “Transcriptional inactivation of secreted frizzled-related protein 1 by promoter hypermethylation as a potential biomarker for non-small cell lung cancer,” Neoplasma, vol. 57, no. 3, pp. 228–233, 2010. View at Publisher · View at Google Scholar · View at Scopus
  13. J. Veeck, P. J. Wild, T. Fuchs et al., “Prognostic relevance of Wnt-inhibitory factor-1 (WIF1) and Dickkopf-3 (DKK3) promoter methylation in human breast cancer,” BMC Cancer, vol. 9, article 217, 2009. View at Publisher · View at Google Scholar · View at Scopus
  14. K. Kawakami, H. Hirata, S. Yamamura et al., “Functional significance of Wnt inhibitory factor-1 gene in kidney cancer,” Cancer Research, vol. 69, no. 22, pp. 8603–8610, 2009. View at Publisher · View at Google Scholar · View at Scopus
  15. K. S. Zhang, Q. Zhou, Y. F. Wang, and L. J. Liang, “Inhibition of Wnt signaling induces cell apoptosis and suppresses cell proliferation in cholangiocarcinoma cells,” Oncology Reports, vol. 30, pp. 1430–1438, 2013. View at Google Scholar
  16. J. B. Rawson, M. Manno, M. Mrkonjic et al., “Promoter methylation of Wnt antagonists DKK1 and SFRP1 is associated with opposing tumor subtypes in two large populations of colorectal cancer patients,” Carcinogenesis, vol. 32, no. 5, pp. 741–747, 2011. View at Publisher · View at Google Scholar · View at Scopus
  17. M. Nojima, H. Suzuki, M. Toyota et al., “Frequent epigenetic inactivation of SFRP genes and constitutive activation of Wnt signaling in gastric cancer,” Oncogene, vol. 26, no. 32, pp. 4699–4713, 2007. View at Publisher · View at Google Scholar · View at Scopus
  18. H. Taniguchi, H. Yamamoto, T. Hirata et al., “Frequent epigenetic inactivation of Wnt inhibitory factor-1 in human gastrointestinal cancers,” Oncogene, vol. 24, no. 53, pp. 7946–7952, 2005. View at Publisher · View at Google Scholar · View at Scopus
  19. H. Suzuki, D. N. Watkins, K.-W. Jair et al., “Epigenetic inactivation of SFRP genes allows constitutive WNT signaling in colorectal cancer,” Nature Genetics, vol. 36, no. 4, pp. 417–422, 2004. View at Publisher · View at Google Scholar · View at Scopus
  20. C. Wissman, P. J. Wild, S. Kaiser et al., “WIFI, a component of the Wnt pathway, is down-regulated in prostate, breast, lung, and bladder cancer,” Journal of Pathology, vol. 201, no. 2, pp. 204–212, 2003. View at Publisher · View at Google Scholar · View at Scopus
  21. M. S. Elston, A. J. Gill, J. V. Conaglen et al., “Wnt pathway inhibitors are strongly down-regulated in pituitary tumors,” Endocrinology, vol. 149, no. 3, pp. 1235–1242, 2008. View at Publisher · View at Google Scholar · View at Scopus
  22. J. Wu, J. Fang, Z. Yang, F. Chen, J. Liu, and Y. Wang, “Wnt inhibitory factor-1 regulates glioblastoma cell cycle and proliferation,” Journal of Clinical Neuroscience, vol. 19, pp. 1428–1432, 2012. View at Google Scholar
  23. D. Huang, B. Yu, Y. Deng et al., “SFRP4 was overexpressed in colorectal carcinoma,” Journal of Cancer Research and Clinical Oncology, vol. 136, no. 3, pp. 395–401, 2010. View at Publisher · View at Google Scholar · View at Scopus
  24. E. Dahl, F. Wiesmann, M. Woenckhaus et al., “Frequent loss of SFRP1 expression in multiple human solid tumours: association with aberrant promoter methylation in renal cell carcinoma,” Oncogene, vol. 26, no. 38, pp. 5680–5691, 2007. View at Publisher · View at Google Scholar · View at Scopus
  25. P. Bovolenta, P. Esteve, J. M. Ruiz, E. Cisneros, and J. Lopez-Rios, “Beyond Wnt inhibition: new functions of secreted Frizzled-related proteins in development and disease,” Journal of Cell Science, vol. 121, no. 6, pp. 737–746, 2008. View at Publisher · View at Google Scholar · View at Scopus
  26. C. Bänziger, D. Soldini, C. Schütt, P. Zipperlen, G. Hausmann, and K. Basler, “Wntless, a Conserved Membrane Protein Dedicated to the Secretion of Wnt Proteins from Signaling Cells,” Cell, vol. 125, no. 3, pp. 509–522, 2006. View at Publisher · View at Google Scholar · View at Scopus
  27. C. Y. Logan and R. Nusse, “The Wnt signaling pathway in development and disease,” Annual Review of Cell and Developmental Biology, vol. 20, pp. 781–810, 2004. View at Publisher · View at Google Scholar · View at Scopus
  28. Y. Kawano and R. Kypta, “Secreted antagonists of the Wnt signalling pathway,” Journal of Cell Science, vol. 116, no. 13, pp. 2627–2634, 2003. View at Publisher · View at Google Scholar · View at Scopus
  29. L. Attisano and J. L. Wrana, “Signal integration in TGF-beta, WNT, and Hippo pathways,” F1000prime Reports 5: 17, 2013. View at Google Scholar
  30. P. Herr, G. Hausmann, and K. Basler, “WNT secretion and signalling in human disease,” Trends in Molecular Medicine, vol. 18, pp. 483–493, 2012. View at Google Scholar
  31. B. He, N. Reguart, L. You et al., “Blockade of Wnt-1 signaling induces apoptosis in human colorectal cancer cells containing downstream mutations,” Oncogene, vol. 24, no. 18, pp. 3054–3058, 2005. View at Publisher · View at Google Scholar · View at Scopus
  32. G. M. Caldwell, C. Jones, K. Gensberg et al., “The Wnt antagonist sFRP1 in colorectal tumorigenesis,” Cancer Research, vol. 64, no. 3, pp. 883–888, 2004. View at Publisher · View at Google Scholar · View at Scopus
  33. J. S. Rubin, M. Barshishat-Kupper, F. Feroze-Merzoug, and Z. F. Xi, “Secreted WNT antagonists as tumor suppressors: Pro and con,” Frontiers in Bioscience, vol. 11, no. 1, pp. 2093–2105, 2006. View at Publisher · View at Google Scholar · View at Scopus
  34. M. Cebrat, L. Strzadala, and P. Kisielow, “Wnt inhibitory factor-1: a candidate for a new player in tumorigenesis of intestinal epithelial cells,” Cancer Letters, vol. 206, no. 1, pp. 107–113, 2004. View at Publisher · View at Google Scholar · View at Scopus
  35. N. Gorfinkiel, J. Sierra, A. Callejo, C. Ibañez, and I. Guerrero, “The Drosophila ortholog of the human Wnt inhibitor factor shifted controls the diffusion of lipid-modified hedgehog,” Developmental Cell, vol. 8, no. 2, pp. 241–253, 2005. View at Publisher · View at Google Scholar · View at Scopus
  36. B. Glise, C. A. Miller, M. Crozatier et al., “Shifted, the Drosophila ortholog of Wnt inhibitory factor-1, controls the distribution and movement of hedgehog,” Developmental Cell, vol. 8, no. 2, pp. 255–266, 2005. View at Publisher · View at Google Scholar · View at Scopus
  37. K. Kamposioras, A. Konstantara, V. Kotoula et al., “The prognostic significance of WNT pathway in surgically-treated colorectal cancer: beta-catenin expression predicts for disease-free survival,” Anticancer Research, vol. 33, pp. 4573–4584, 2013. View at Google Scholar
  38. R. Bai, D. Li, Z. Shi, X. Fang, W. Ge, and S. Zheng, “Clinical significance of Ankyrin repeat domain 12 expression in colorectal cancer,” Journal of Experimental & Clinical Cancer Research, vol. 32, p. 35, 2013. View at Google Scholar