Network-Assisted Prediction of Potential Drugs for Addiction

Table 1

Summary of addictive drugs, their targets, and classification.

DrugBank ID	Drug name	Number of targets	DrugBank group	NIDA category^a
DB00316	Acetaminophen	2	Approved	Opioids and morphine derivatives
DB00404	Alprazolam	20	Approved, illicit	Depressants
DB01351	Amobarbital	10	Approved, illicit	Depressants
DB00182	Amphetamine	4	Approved, illicit	Stimulants
DB01541	Boldenone	1	Experimental, illicit	Other compounds
DB00475	Chlordiazepoxide	19	Approved, illicit	Depressants
DB00907	Cocaine	8	Approved, illicit	Stimulants
DB00318	Codeine	3	Approved, illicit	Opioids and morphine derivatives
DB01189	Desflurane	7	Approved	Other compounds
DB00514	Dextromethorphan	4	Approved	Other compounds
DB00829	Diazepam	18	Approved, illicit	Depressants
DB00228	Enflurane	8	Approved	Other compounds
DB00898	Ethanol	7	Approved	Other compounds
DB00813	Fentanyl	3	Approved, illicit	Opioids and morphine derivatives
DB01544	Flunitrazepam	6	Approved, illicit	Depressants
DB01440	Gamma hydroxybutyric acid	1	Approved, illicit	Depressants
DB01159	Halothane	17	Approved	Other compounds
DB01452	Heroin	3	Approved, illicit	Opioids and morphine derivatives
DB00956	Hydrocodone	2	Approved, illicit	Opioids and morphine derivatives
DB00327	Hydromorphone	3	Approved, illicit	Opioids and morphine derivatives
DB00753	Isoflurane	7	Approved	Other compounds
DB01221	Ketamine	3	Approved	Dissociative anesthetics
DB00186	Lorazepam	20	Approved	Depressants
DB04829	Lysergic acid diethylamide	0	Illicit, withdrawn	Hallucinogens
DB00454	Meperidine	6	Approved	Opioids and morphine derivatives
DB01577	Methamphetamine	11	Approved, illicit	Stimulants
DB04833	Methaqualone	0	Illicit, withdrawn	Depressants
DB01028	Methoxyflurane	7	Approved	Other compounds
DB00422	Methylphenidate	3	Approved, investigational	Stimulants
DB01442	MMDA	8	Experimental, illicit	Stimulants
DB00295	Morphine	3	Approved	Opioids and morphine derivatives
DB00486	Nabilone	2	Approved	Other compounds
DB00984	Nandrolone phenpropionate	0	Approved, illicit	Other compounds
DB00184	Nicotine	11	Approved	Stimulants
DB00621	Oxandrolone	1	Approved	Other compounds
DB00497	Oxycodone	3	Approved, illicit	Opioids and morphine derivatives
DB00312	Pentobarbital	10	Approved	Depressants
DB03575	Phencyclidine	2	Experimental, illicit	Dissociative anesthetics
DB01174	Phenobarbital	10	Approved	Depressants
DB00647	Propoxyphene	3	Approved, illicit	Opioids and morphine derivatives
DB00418	Secobarbital	10	Approved	Depressants
DB01236	Sevoflurane	7	Approved	Other compounds
DB00624	Testosterone	1	Approved	Other compounds
DB00897	Triazolam	20	Approved, illicit, withdrawn	Depressants

aDrug category is defined based on the similarities regarding how drugs function and what effects they produce in the human body, including the brain, as annotated by NIDA.