Review Article
New Insights into Monoclonal B-Cell Lymphocytosis
Table 1
Prevalence of CLL-type MBL in some of the larger reported series.
| | Population studied | Median age,
Y (range) | | Number of colours | Events
× | All ages in study, % | CLL-type MBL > 60 y, % | MBL
counts
(median) |
| |
US residential population [9] | 53
(40–76) | 1926 | 2 | N.R. | 0.6 | >0.6 | 88/μL | | US blood donors [10] | 45
(18–79) | 5141 | 2 | N.R. | 0.14 | 0.9 | NR | | UK hospital outpatients [4] | 57
(40–90) | 910 | 4 | 200 | 3.5 | 5.0 | 0.013 × 109 | | Italy primary care [5] | 74
(65–98) | 500 | 4 | 200 | 5.5 | 5.5 | 0.114 × 109
(mean) | | UK hospital outpatients with normal ALC [11] | 74
(62–80) | 1520 | 4 | 200 | 5.1 | 5.1 | NR | | UK hospital outpatients with lymphocytosis [11] | 71
(39–99) | 2228 | 4 | 200 | 13.9 | NR |
NR) | | Italy residential population [12] | 55
(18–102) | 1725 | 5 | 500 | 5.2 | 8.9 | 0.034 × 109 | | Spain primary care [3] | 62
(40–97) | 608 | 8 | 5000 | 14.3 | >20 |
0.17 × 109` | | US blood donors [13] | 57
(45–91) | 2098 | 6 | 500 | 4.8 | 10.7* | 0.01 × 109(10/μL) | | 1st-degree relatives of sporadic CLL [14] | 62
(18–84) | 167 | 4 | 300 | 4.2 | 15.6 | NR | | 1st-degree relatives of familial CLL [15] | NR | 33 | 2-3 | NR | 18 | NR | NR | | 1st-degree relatives of familial CLL [16] | 47
(23–86) | 59 | 4 | NR | 13.6 | >20 | 5/μL |
|
|
NR: not reported.
|
