New Insights into Monoclonal B-Cell Lymphocytosis

Table 2

Representative studies on the risk of progression of HC-MBL and suggested cutoff values of clonal B cells for predicting the risk of progression.

STUDY	Pts	MEDIAN; FUP; (years)	Range	CLL/SLL; requiring; therapy	B-cell count cutoff value
Shim et al., 2007 [9]	= 185; Clinical MBL	6.7	0.2–11.8	1.1% per year	<1900/μL no progression
Shanafelt et al., 2009 [17]	= 459; MBL = 190	1.5	0.3–7.9	1.4% per year	<11000/μL predict better TFS and OS
Rossi et al., 2009 [18]	= 123; Clinical MBL	3.6	NS	4% per year for the first 7 years and then 0%	<1200/μL low risk progression
Scarfo et al., 2012 [19]	= 184; Clinical MBL	3.75	0–306	1.5%	10374 2.4 versus 8.5; 5000  1.5 versus 5.2