Note: A means amino acid composition (20 dimensions), A + ACC means amino acid composition and the interaction of segments (164 dimensions), A + ACC + M means amino acid composition, the interaction of segments, and motif frequency (290 dimensions), and A + ACC + M + P means amino acid composition, the interaction of segments, motif frequency, and predicted secondary structure information (296 dimensions); means the overall accuracy; the standard deviation values are in the parenthesis of the sixth column, the penultimate column is the results of Liu et al. [27] with the same dataset, and the last column is our results of the dataset built by Ding and Dubchak [11].