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BioMed Research International
Volume 2014, Article ID 265274, 9 pages
Research Article

Evidence for Association of the E23K Variant of KCNJ11 Gene with Type 2 Diabetes in Tunisian Population: Population-Based Study and Meta-Analysis

1Pasteur Institute of Tunis, Laboratory of Biomedical Genomics and Oncogenetics, LR11IPT05, BP 74, 13 Place Pasteur, Le Belvédère, 1002 Tunis, Tunisia
2Université Tunis El Manar, 1068 Tunis, Tunisia
3National Institute of Nutrition and Food Technology, Department of External Consultation, 11 rue Jebel Lakhdar, Bab Saadoun, 1007 Tunis, Tunisia
4Pasteur Institute of Morocco, Department of Scientific Research, Laboratory of Molecular and Human Genetics, 1 Place Louis Pasteur, 20360 Casablanca, Morocco
5Centre of Biotechnology of Sfax, Unit of Bioinformatics and Biostatistics, 3038 Sfax, Tunisia
6Pasteur Institute of Tunis, Central Laboratory of Medical Biology, 13 Place Pasteur, Le Belvédère, 1002 Tunis, Tunisia

Received 26 February 2014; Accepted 30 May 2014; Published 7 July 2014

Academic Editor: Konstantinos Kantartzis

Copyright © 2014 Khaled Lasram et al. This is an open access article distributed under the Creative Commons Attribution License, which permits unrestricted use, distribution, and reproduction in any medium, provided the original work is properly cited.


Aims. Genetic association studies have reported the E23K variant of KCNJ11 gene to be associated with Type 2 diabetes. In Arab populations, only four studies have investigated the role of this variant. We aimed to replicate and validate the association between the E23K variant and Type 2 diabetes in Tunisian and Arab populations. Methods. We have performed a case-control association study including 250 Tunisian patients with Type 2 diabetes and 267 controls. Allelic association has also been evaluated by 2 meta-analyses including all population-based studies among Tunisians and Arabs (2 and 5 populations, resp.). Results. A significant association between the E23K variant and Type 2 diabetes was found (OR = 1.6, 95% CI = 1.14–2.27, and ). Furthermore, our meta-analysis has confirmed the significant role of the E23K variant in susceptibility of Type 2 diabetes in Tunisian and Arab populations (OR = 1.29, 95% CI = 1.15–1.46, and and OR = 1.33, 95% CI = 1.13–1.56, and , resp.). Conclusion. Both case-control and meta-analyses results revealed the significant association between the E23K variant of KCNJ11 and Type 2 diabetes among Tunisians and Arabs.