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BioMed Research International
Volume 2014, Article ID 271070, 5 pages
Research Article

Clinical Features and Molecular Analysis of Hb H Disease in Taiwan

1Institute of Medicine, Chung Shan Medical University, No. 110, Section 1, Chien-Kuo N. Road, Taichung 402, Taiwan
2Department of Pediatrics, Chung Shan Medical University Hospital, Taichung, Taiwan
3School of Medicine, Chung Shan Medical University, Taichung, Taiwan
4School of Chinese Medicine, China Medical University, Taichung, Taiwan
5Department of Hemato-Oncology, Children’s Hospital, China Medical University Hospital, China Medical University, Taichung, 5, Taiwan
6Department of Pediatrics, Buddhist Tzu Chi General Hospital, Taichung Branch, Taichung, Taiwan
7Department of Biotechnology and Bioinformatics, Asia University, Taichung, Taiwan
8Department of Obstetrics and Gynecology, Chung Shan Medical University Hospital, Taichung, Taiwan

Received 23 June 2014; Revised 5 August 2014; Accepted 5 August 2014; Published 28 August 2014

Academic Editor: Aurelio Maggio

Copyright © 2014 Yu-Hua Chao et al. This is an open access article distributed under the Creative Commons Attribution License, which permits unrestricted use, distribution, and reproduction in any medium, provided the original work is properly cited.

Supplementary Material

The occurrence of splenomegaly could be an important indicator of clinical significance. In the present study, patients with hepatomegaly or jaundice always had splenomegaly concomitantly. Among the 14 patients with nondeletional Hb H disease who had splenomegaly, nearly all of them also had jaundice and half of them had hepatomegaly.

  1. Supplementary Material