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BioMed Research International
Volume 2014 (2014), Article ID 273754, 7 pages
Clinical Study

Visual and Anatomical Outcomes of Intravitreal Aflibercept for Treatment-Resistant Neovascular Age-Related Macular Degeneration

1Sapienza University of Rome, Policlinico Umberto I Hospital, 155 Viale del Policlinico, 00161 Rome, Italy
2Casa di Cura Privata Villa Benedetta, 65 Circonvallazione Cornelia, 00165 Rome, Italy
3Casa di Cura Privata Villa Margherita, 48 Viale di Villa Massimo, 00161 Rome, Italy

Received 19 February 2014; Accepted 17 April 2014; Published 7 May 2014

Academic Editor: Toshiaki Kubota

Copyright © 2014 Magda Gharbiya et al. This is an open access article distributed under the Creative Commons Attribution License, which permits unrestricted use, distribution, and reproduction in any medium, provided the original work is properly cited.


A retrospective chart review of patients with persistent subretinal and/or intraretinal fluid, despite previous treatment with intravitreal ranibizumab (0.5 mg), who were switched to aflibercept injections, was performed. Treatment was three monthly aflibercept (2 mg) injections followed by dosing on pro re nata basis. Main outcome measures included changes in best corrected visual acuity (BCVA), 1 mm central subfield (CSF) retinal thickness, the height of the pigment epithelial detachment (PED), and subfoveal choroidal thickness on optical coherence tomography at 6 months. Thirty-one eyes of 30 patients were analyzed. The mean number of injections before aflibercept conversion was 34.4 ± 11.9. After an average of 4.5 aflibercept injections (range 3 to 6) over 6 months, no significant change in BCVA was observed (). Compared with baseline, there was a significant reduction of the CSF retinal thickness (449 ± 179 versus 269 ± 145 μm, ), maximum PED height (262 ± 134 versus 183 ± 100 μm, ), and choroidal thickness (192 ± 67 versus 167 ± 51 μm, ). Stable visual acuity and anatomical improvement were obtained for up to 6 months after aflibercept conversion. However, choroidal thinning related to treatment was observed.