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BioMed Research International
Volume 2014, Article ID 276918, 7 pages
Review Article

Serotonin Reuptake Inhibitors in Pregnancy: Can Genes Help Us in Predicting Neonatal Adverse Outcome?

1Department of Paediatrics, Hospital Luigi Sacco, Via GB Grassi 74, 20157 Milan, Italy
2Unit of Clinical Pharmacology, Hospital Luigi Sacco, Via GB Grassi 74, 20157 Milan, Italy

Received 17 October 2013; Revised 22 December 2013; Accepted 23 December 2013; Published 12 January 2014

Academic Editor: Allegaert Karel

Copyright © 2014 Valentina Giudici et al. This is an open access article distributed under the Creative Commons Attribution License, which permits unrestricted use, distribution, and reproduction in any medium, provided the original work is properly cited.


Lots has been written on use of SSRI during pregnancy and possible short and long term negative outcomes on neonates. the literature so far has described a various field of peripartum illness related to SSRI exposure during foetal life, such as increased incidence of low birth weight, respiratory distress, persistent pulmonary hypertension, poor feeding, and neurobehavioural disease. We know that different degrees of outcomes are possible, and not all the newborns exposed to SSRIs during pregnancy definitely will develop a negative outcome. So far, still little is known about the possible etiologic mechanism that could not only explain the adverse neonatal effects but also the degree of clinical involvement and presentation in the early period after birth. Pharmacogenetics and moreover pharmacogenomics, the study of specific genetic variations and their effect on drug response, are not widespread. This review describes possible relationship between SSRIs pharmacogenetics and different neonatal outcomes and summarizes the current pharmacogenetic inquiries in relation to maternal-foetal environment.