Contribution of Ca2+-Dependent Cl− Channels to Norepinephrine-Induced Contraction of Femoral Artery Is Replaced by Increasing EDCF Contribution during Ageing
Figure 2
Norepinephrine concentration-response curves obtained in femoral arteries of 20-month-old WKY rats (WKY) recorded under the control conditions and after Ca2+-dependent Cl− channels blockade (R(+)-IAA-94, IAA) or after the inhibition of cyclooxygenase (indomethacin, IME) or in the presence of niflumic acid (NIFLU). Data are presented as mean ± S.E.M. (for number of vessels see Table 4). Depicted curves were calculated from average values obtained at studied norepinephrine concentrations.
