Dual Binding Site and Selective Acetylcholinesterase Inhibitors Derived from Integrated Pharmacophore Models and Sequential Virtual Screening

<table>Pharmacophore model of AChEIs generated by HYPOREFINE. (a) The best HYPOREFINE model Hypo1_A. (b) Hypo1_A mapping with one of the most active compound<b> 1</b> (IC<sub>50</sub> = 0.3 nM). Pharmacophore features are color-coded with light-blue for hydrophobic-aromatic feature, orange for ring aromatic feature, magenta for hydrogen-bond donor, and grey for excluded volumes.</table>

BioMed Research International

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Figure 3: Dual Binding Site and Selective Acetylcholinesterase Inhibitors Derived from Integrated Pharmacophore Models and Sequential Virtual Screening 

Figure 3 | Dual Binding Site and Selective Acetylcholinesterase Inhibitors Derived from Integrated Pharmacophore Models and Sequential Virtual Screening 