Dual Binding Site and Selective Acetylcholinesterase Inhibitors Derived from Integrated Pharmacophore Models and Sequential Virtual Screening

Table 6

Results of Fischer’s randomization test for Hypo1_B at 90% using Cat-Scramble implemented in DS2.5 software.

Validation number	Total cost	Null cost	Cost diff.	Correlation (r)
Hypo1_B	112.52	167.07	54.55	0.9429
Results for scrambled
Trial 1	144.34	167.07	22.73	0.6456
Trial 2	136.53	167.07	30.54	0.7953
Trial 3	136.55	167.07	30.52	0.7425
Trial 4	130.93	167.07	36.14	0.7851
Trial 5	129.73	167.07	37.34	0.8420
Trial 6	146.39	167.07	20.68	0.6503
Trial 7	143.40	167.07	23.67	0.7184
Trial 8	129.32	167.07	37.75	0.8321
Trial 9	147.42	167.07	19.65	0.6229